Liu Qingqing, He Hairong, Yang Jin, Feng Xiaojie, Zhao Fanfan, Lyu Jun
Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China; School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
J Psychiatr Res. 2020 Jul;126:134-140. doi: 10.1016/j.jpsychires.2019.08.002. Epub 2019 Aug 10.
Depression is the most common mental illness worldwide. It has become an important public health problem. This study aimed to determine the global burden of depression and how it has changed between 1990 and 2017.
We used information on depression obtained by the Global Burden of Disease (GBD) study from 1990 to 2017. The age-standardized incidence rate (ASR) and estimated annual percentage change (EAPC) were used to assess the global burden of depression.
The number of incident cases of depression worldwide increased from 172 million in 1990 to 25,8 million in 2017, representing an increase of 49.86%. The ASR of depression varied widely between the 195 analyzed countries and regions in 2017, being highest in Lesotho (6.59 per 1000) and lowest in Myanmar (1.28 per 1000). The ASR increased the most between 1990 and 2017 in Belgium (EAPC = 0.88, 95% confidence interval [CI] = 0.78 to 0.97), and decreased the most in Cuba (EAPC = -1.26, 95% CI = -1.36 to -1.14). The ASR increased in regions with a high sociodemographic index, such as high-income North America (EAPC = 0.41, 95% CI = 0.31 to 0.51), and decreased significantly in South Asia (EAPC = -0.63, 95% CI = -0.85 to -0.41). The proportions of the population with major depressive disorder and dysthymia were essentially stable both globally and in various countries, with a much larger proportion having major depressive disorder.
Depression remains a major public health issue, and governments should support the research necessary to develop better prevention and treatment interventions.
抑郁症是全球最常见的精神疾病。它已成为一个重要的公共卫生问题。本研究旨在确定抑郁症的全球负担以及1990年至2017年间其负担的变化情况。
我们使用了全球疾病负担（GBD）研究在1990年至2017年间获取的有关抑郁症的信息。年龄标准化发病率（ASR）和估计年百分比变化（EAPC）用于评估抑郁症的全球负担。
全球抑郁症新发病例数从1990年的1.72亿例增加到2017年的2.58亿例，增长了49.86%。2017年，在195个被分析的国家和地区中，抑郁症的年龄标准化发病率差异很大，莱索托最高（每1000人中有6.59例），缅甸最低（每1000人中有1.28例）。1990年至2017年间，比利时的年龄标准化发病率增长最多（EAPC = 0.88，95%置信区间[CI] = 0.78至0.97），古巴下降最多（EAPC = -1.26，95% CI = -1.36至-1.14）。在社会人口学指数较高的地区，如高收入的北美地区，年龄标准化发病率上升（EAPC = 0.41，95% CI = 0.31至0.51），而在南亚地区则显著下降（EAPC = -0.63，95% CI = -0.85至-0.41）。全球和各个国家中，重度抑郁症和心境恶劣障碍患者的比例基本稳定，其中重度抑郁症患者的比例要大得多。
抑郁症仍然是一个主要的公共卫生问题，各国政府应支持开展必要的研究，以开发更好的预防和治疗干预措施。
