WS-LungNet: A two-stage weakly-supervised lung cancer detection and diagnosis network.

Computer-aided lung cancer diagnosis (CAD) system on computed tomography (CT) helps radiologists guide preoperative planning and prognosis assessment. The flexibility and scalability of deep learning methods are limited in lung CAD. In essence, two significant challenges to be solved are (1) Label scarcity due to cost annotations of CT images by experienced domain experts, and (2) Label inconsistency between the observed nodule malignancy and the patients' pathology evaluation. These two issues can be considered weak label problems. We address these issues in this paper by introducing a weakly-supervised lung cancer detection and diagnosis network (WS-LungNet), consisting of a semi-supervised computer-aided detection (Semi-CADe) that can segment 3D pulmonary nodules based on unlabeled data through adversarial learning to reduce label scarcity, as well as a cross-nodule attention computer-aided diagnosis (CNA-CADx) for evaluating malignancy at the patient level by modeling correlations between nodules via cross-attention mechanisms and thereby eliminating label inconsistency. Through extensive evaluations on the LIDC-IDRI public database, we show that our proposed method achieves 82.99% competition performance metric (CPM) on pulmonary nodule detection and 88.63% area under the curve (AUC) on lung cancer diagnosis. Extensive experiments demonstrate the advantage of WS-LungNet on nodule detection and malignancy evaluation tasks. Our promising results demonstrate the benefits and flexibility of the semi-supervised segmentation with adversarial learning and the nodule instance correlation learning with the attention mechanism. The results also suggest that making use of the unlabeled data and taking the relationship among nodules in a case into account are essential for lung cancer detection and diagnosis.