Mordes J P, el Lozy M, Herrera M G, Silen W
Am J Physiol. 1979 Jan;236(1):R61-6. doi: 10.1152/ajpregu.1979.236.1.R61.
Bilateral truncal vagotomy performed in 13 rats reduced weight gain by 26% compared to controls, but also produced gastric distension. Addition of pyloroplasty was found to facilitate gastric drainage in vagotomized rats, and both procedures were then performed in 57 rats of both sexes and varying initial weights. When fed ad libitum, vagotomized animals maintained a weight 14-30% less than controls over periods of 30-300 days. When pair fed, normal rats and rats with vagotomy and pyloroplasty weighed the same. Various partial vagotomies had no effect on weight gain. It was concluded that vagotomy reduces weight gain in rats, that the reduction is the result of decreased food intake, and that the effect of vagotomy is probably not due to gastric distension.
对13只大鼠实施双侧迷走神经干切断术，与对照组相比，体重增加减少了26%，但同时也导致了胃扩张。结果发现，加做幽门成形术有助于迷走神经切断术后大鼠的胃排空，随后对57只不同初始体重的雌雄大鼠都实施了这两种手术。自由进食时，在30至300天的时间段内，迷走神经切断术的动物体重比对照组低14%至30%。成对喂食时，正常大鼠与接受迷走神经切断术和幽门成形术的大鼠体重相同。各种部分迷走神经切断术对体重增加没有影响。得出的结论是，迷走神经切断术会降低大鼠的体重增加，这种降低是食物摄入量减少的结果，而且迷走神经切断术的效果可能不是由于胃扩张所致。
