Frappat P, Pincemaille O, Plantaz D
Unité de réanimation infantile, Centre Hospitalier Universitaire de Grenoble, France.
Pediatrie. 1987;42(4):303-7.
The authors report a retrospective study of 11 cases of malignant hyperthermia. The mean age of the patients was 5 months and 3 weeks. Clinical features included severe hyperthermia (greater than 41 degrees C), seizures, coma, collapse, rhabdomyolysis, acute renal failure and functional renal failure. Three infants died. Four patients presented neurological damages. Four recovered fully. The authors discuss the difficulties of diagnosis, the nosological position and the pathophysiology of this syndrome.
作者报告了一项对11例恶性高热病例的回顾性研究。患者的平均年龄为5个月零3周。临床特征包括严重高热（体温高于41摄氏度）、惊厥、昏迷、虚脱、横纹肌溶解、急性肾衰竭和功能性肾衰竭。3名婴儿死亡。4名患者出现神经损伤。4名患者完全康复。作者讨论了该综合征的诊断困难、疾病分类位置及病理生理学。
