Costa Joana Raquel, Rego Ângela Reis, Soares Teresa, Sousa Cecília Almeida E, Coutinho Miguel Bebiano
Department of Otorhinolaryngology-Head and Neck Surgery, Centro Hospitalar Universitário do Porto, Porto, Portugal.
J Audiol Otol. 2023 Jan;27(1):30-36. doi: 10.7874/jao.2022.00143. Epub 2023 Jan 10.
The etiopathogenesis of acquired pediatric cholesteatoma has not yet been fully clarified. Recent studies and modern technologies have led researchers to look for explanations at a molecular level. This study aims to understand if the origins of cholesteatoma could be related to dysfunctions in coagulation factors, thereby emphasizing its role in angiogenesis. Subjects and.
This was a retrospective case-control study carried out at a tertiary hospital center between January 2010 and December 2020. The study included 92 children. The variables of the summary coagulation study (partial thromboplastin time, prothrombin time, and international normalized ratio) were compared among children with and without development of chronic otitis media with cholesteatoma.
The cases and controls were comparable in terms of age, type, and number of times that ventilation tubes were placed. Partial thromboplastin times tended to be higher in children who developed cholesteatoma, with a statistically significant difference between the two groups in terms of normal and abnormal partial thromboplastin times (p=0.029).
The results of this case control study indicate that slight extension of partial thromboplastin times in the coagulation study may not meet the criteria for diagnosis of certain hematological pathologies or clinical significance, but at a molecular level may already have implications for activation of angiogenesis and other growth factors involved in the onset, growth, and expansion of acquired pediatric cholesteatoma.
儿童获得性胆脂瘤的发病机制尚未完全阐明。近期的研究和现代技术促使研究人员在分子水平上寻找解释。本研究旨在了解胆脂瘤的起源是否可能与凝血因子功能障碍有关，从而强调其在血管生成中的作用。对象与……
这是一项在2010年1月至2020年12月期间于一家三级医院中心开展的回顾性病例对照研究。该研究纳入了92名儿童。对患有和未患慢性胆脂瘤型中耳炎儿童的凝血综合研究变量（部分凝血活酶时间、凝血酶原时间和国际标准化比值）进行了比较。
病例组和对照组在年龄、通气管放置类型和次数方面具有可比性。发生胆脂瘤的儿童部分凝血活酶时间往往较高，两组在正常和异常部分凝血活酶时间方面存在统计学显著差异（p = 0.029）。
本病例对照研究结果表明，凝血研究中部分凝血活酶时间的轻微延长可能不符合某些血液学疾病的诊断标准或临床意义，但在分子水平上可能已经对血管生成及其他参与儿童获得性胆脂瘤发生、生长和扩展的生长因子激活产生影响。
