State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Road South, Nanjing 211816, P. R. China.
J Org Chem. 2023 Feb 17;88(4):2057-2068. doi: 10.1021/acs.joc.2c02336. Epub 2023 Jan 29.
This study describes a visible-light-induced cascade reaction for preparing cyanoalkyl-containing polyheterocycles initiated by the photoinduced radical cascade addition of -arylacrylamide derivatives using cyclic oxime esters as radical sources followed by cyanoalkyl-mediated cyclization. This protocol features outstanding functional group compatibility, providing a variety of desired phenanthridine derivatives in moderate to good yields. Moreover, the application of a microflow technique enhanced these reactions compared with the equivalent batch reaction, significantly reducing reaction times to 10 min.
本研究描述了一种可见光诱导的级联反应，用于制备含氰烷基的多杂环化合物，该反应由 -芳基丙烯酰胺衍生物的光诱导自由基级联加成引发，使用环状肟酯作为自由基源，然后进行氰烷基介导的环化。该方案具有出色的官能团相容性，能够以中等至良好的收率提供多种所需的菲啶衍生物。此外，与等效的批量反应相比，微流技术的应用增强了这些反应，将反应时间显著缩短至 10 分钟。
