School of Chemistry and Materials Science, Jiangsu Provincial Key Laboratory of Material Cycle Processes and Pollution Control, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing Normal University , Nanjing 210023, China.
Org Lett. 2017 Jul 7;19(13):3580-3583. doi: 10.1021/acs.orglett.7b01553. Epub 2017 Jun 28.
A novel visible-light-induced cascade reaction for the preparation of ester-functionalized polyheterocycles was developed under metal-free conditions, which was initiated by an intermolecular radical addition to a carbon-carbon double bond of N-arylacrylamide derivatives using alkyl carbazate as the ester source followed by cyano-mediated cyclization. The desired phenanthridine derivative products were isolated in moderate to high yields with broad substrate scope.
发展了一种新型的可见光诱导级联反应，用于在无金属条件下制备酯基功能化的多杂环化合物，该反应通过烷基碳二亚胺作为酯源与 N-芳基丙烯酰胺衍生物的碳-碳双键进行分子间自由基加成，然后通过氰基介导的环化来引发。以中等至高产率和广泛的底物范围分离得到所需的菲啶衍生物产物。
