Department of Pediatric Cardiology, Emergency Institute for Cardiovascular Diseases and Heart Transplant, Targu Mures, Romania.
Doctoral School of I.O.S.U.D., George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, Targu Mures, Romania.
Dev Neurorehabil. 2023 Apr;26(3):206-215. doi: 10.1080/17518423.2023.2166618. Epub 2023 Jan 29.
The aim of this systematic literature review was to assess the data regarding neuromarkers used to evaluate the impact of cardiovascular surgery on neurodevelopmental pattern of children with congenital heart defects. A systematic search was performed on PubMed and Google Scholar databases. Out of 713 publications screened, 10 studies (471 patients) met the inclusion criteria. The included studies were coded on several variables: number and heterogeneity of patients (age, congenital heart defects), exclusion of patients with conditions that predispose to neurological impairment, neuroimaging workup pre- and post-surgery, neurodevelopmental assessment, interventions (part of a different study), and follow-up period. Results were reported according to PRISMA guidelines. Findings include: neuron-specific enolase and brain-derived neurotrophic factor are not reliable neuromarkers, for protein S100B different results were reported, for activin A there is lack of evidence, and glial fibrillary acidic protein could represent a reliable neuromarker for acute brain-injury. Directions for future research are discussed.
本系统文献回顾的目的是评估用于评估先天性心脏病儿童心血管手术后神经发育模式的神经标志物数据。在 PubMed 和 Google Scholar 数据库中进行了系统搜索。在筛选出的 713 篇出版物中，有 10 项研究（471 名患者）符合纳入标准。纳入的研究在几个变量上进行了编码：患者数量和异质性（年龄、先天性心脏缺陷）、排除易导致神经损伤的患者、手术前后神经影像学检查、神经发育评估、干预措施（不同研究的一部分）和随访期。结果根据 PRISMA 指南报告。研究结果包括：神经元特异性烯醇化酶和脑源性神经营养因子不是可靠的神经标志物，蛋白 S100B 报告的结果不同，激活素 A 缺乏证据，神经胶质纤维酸性蛋白可能是急性脑损伤的可靠神经标志物。讨论了未来研究的方向。
