Department of Pathology, King George's Medical University, Lucknow, Uttar Pradesh, India.
Department of Paediatrics, King George's Medical University, Lucknow, Uttar Pradesh, India.
Int J Surg Pathol. 2023 Oct;31(7):1381-1386. doi: 10.1177/10668969221149131. Epub 2023 Jan 29.
Germ cell tumors primarily arise in gonads and extragonadal germ cell tumors, an uncommon entity, originates usually along the midline. Here, we report the fifth example of intrarenal pure yolk sac tumor in a 1.5-year-old boy who presented with abdominal pain and underwent excision of the mass for suspected Wilms tumor. On histopathology and immunohistochemistry, a diagnosis of a yolk sac tumor was rendered. Postoperative serum alpha-fetoprotein levels were 21 000 ng/dl. The purpose of this report is to emphasize the importance of suspecting a germ cell tumor as one of the differential diagnoses of a suspected case of Wilms tumor and the significance of evaluating serum alpha-fetoprotein levels preoperatively.
生殖细胞肿瘤主要发生在性腺和性腺外生殖细胞肿瘤，一种罕见的实体瘤，通常沿着中线起源。在这里，我们报告了第五例发生在 1.5 岁男孩肾脏内的纯卵黄囊瘤，该男孩因腹痛就诊，疑似肾母细胞瘤而行肿块切除术。组织病理学和免疫组织化学检查诊断为卵黄囊瘤。术后血清甲胎蛋白水平为 21000ng/dl。本报告的目的是强调怀疑生殖细胞肿瘤作为疑似肾母细胞瘤的鉴别诊断之一的重要性，以及术前评估血清甲胎蛋白水平的重要性。
