Al-Masri Anwar A, Khasawneh Nidal H, Aladily Tariq N
Department of Pathology, Jordan University Hospital, Amman, Jordan.
Ann Saudi Med. 2011 May-Jun;31(3):298-300. doi: 10.4103/0256-4947.76410.
A nongerminomatous germ cell tumor occurring in the brain parenchyma is extremely rare. A 2-year-old boy presented with symptoms of abnormal movements in the hand and mouth. MRI scanning revealed a lesion occupying the left temporoparietal region. Craniotomy was performed and the tumor was removed by en bloc resection. Histological examination revealed that the tumor was arranged in a reticular pattern, and Schiller-Duval bodies were evident at the center of the tumor. Immunohistochemical study showed that the tumor cells were positive for alpha-fetoprotein and vimentin, but negative for glial fibrillary acidic protein. The histological diagnosis was pure yolk sac tumor.
发生于脑实质的非生殖细胞瘤极为罕见。一名2岁男孩出现手和口部异常运动症状。MRI扫描显示左侧颞顶叶区域有一占位性病变。行开颅手术，肿瘤整块切除。组织学检查显示肿瘤呈网状排列，肿瘤中心可见席勒-杜瓦尔小体。免疫组化研究显示肿瘤细胞甲胎蛋白和波形蛋白呈阳性，但胶质纤维酸性蛋白呈阴性。组织学诊断为纯卵黄囊瘤。
