与布鲁氏菌病相关的危及生命的严重血小板减少症和轻度自身免疫性溶血性贫血
Life-Threatening Severe Thrombocytopenia and Mild Autoimmune Hemolytic Anemia Associated with Brucellosis.
作者信息
Ahmed Waleed Amsaib M, Ahmed Khalil Khalid, Azwari Asma, Ebid Gamal T A, Nazir Imran, Aly Mohamed Hassan
机构信息
Department of Medicine, Security Forces Hospital, Makkah, Saudi Arabia.
Clinical Pathology Consultant, Security Forces Hospital, Makkah, Saudi Arabia.
出版信息
Case Rep Infect Dis. 2023 Jan 20;2023:6608279. doi: 10.1155/2023/6608279. eCollection 2023.
METHODS
We report the case of a 73-year-old Saudi female who presented with severe thrombocytopenia and mild autoimmune hemolytic anemia associated with brucellosis. The coexistence of published cases of two hematological disorders with brucellosis is rare.
RESULTS
Despite the initial treatment with eltrombopag and intravenous immunoglobulin (IVIG), our patient's platelets count remained low and significantly improved after initiation of brucellosis treatment in the form of rifampicin and doxycycline. . We conclude by reviewing the case that in many parts of Saudi Arabia, brucellosis remains a prevalent infection. Hence, it should be considered as a possible diagnosis in febrile individuals with no localizing indications and the presence of severe thrombocytopenia in acute febrile illness. Although it is a rare association, it could be related to brucellosis.
CONCLUSION
This is our region's first published case of severe thrombocytopenia and mild autoimmune hemolytic anemia associated with brucellosis. It contributes to the literature on the successful use of rifampicin and doxycycline to treat hematological disorders associated with brucellosis.
方法
我们报告了一名73岁沙特女性的病例，该患者出现严重血小板减少症以及与布鲁氏菌病相关的轻度自身免疫性溶血性贫血。两种血液系统疾病与布鲁氏菌病并存的已发表病例较为罕见。
结果
尽管最初使用艾曲泊帕和静脉注射免疫球蛋白（IVIG）进行治疗，但我们患者的血小板计数仍很低，在以利福平与强力霉素形式开始布鲁氏菌病治疗后显著改善。通过对该病例的回顾，我们得出结论，在沙特阿拉伯的许多地区，布鲁氏菌病仍然是一种普遍的感染。因此，对于无定位体征且在急性发热性疾病中出现严重血小板减少症的发热个体，应将其视为可能的诊断。尽管这是一种罕见的关联，但可能与布鲁氏菌病有关。
结论
这是我们地区首例发表的与布鲁氏菌病相关的严重血小板减少症和轻度自身免疫性溶血性贫血病例。它为关于成功使用利福平与强力霉素治疗与布鲁氏菌病相关的血液系统疾病的文献做出了贡献。
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