Reimann Christopher E, Kim Kelly E, Rand Alexander W, Moghadam Farbod A, Stoltz Brian M
California Institute of Technology, Pasadena, CA 91125.
Tetrahedron. 2023 Jan 9;130. doi: 10.1016/j.tet.2022.133176. Epub 2022 Nov 29.
Despite amazing advances in cross-coupling technologies over the past several decades, there is not a consistent definition of what a cross-coupling reaction is. Often, definitions rely on comparison to "traditional" palladium-catalyzed cross-couplings pioneered in the 1970s by chemists such as Suzuki, Negishi, and Heck. While these reactions provide a basis for a cross-coupling definition, they do not define this type of transformation, originally described by Linstead almost 20 years prior. Rather than modify and compartmentalize modern transformations to categorize them into either a synthetic or mechanistic definition, we make an argument for broadening the cross-coupling definition to to encourage discussion around exploring novel reactivity and disconnections. In addition to making a case for a universal cross-coupling definition, we cite specific examples of reactions that break the mold of prior cross-coupling definitions. We believe this perspective will stimulate dialog around what it means to be a cross-coupling and in turn inspire future developments within this field.
尽管在过去几十年里交叉偶联技术取得了惊人的进展，但对于什么是交叉偶联反应并没有一个统一的定义。通常，定义依赖于与20世纪70年代由铃木章、根岸英一和赫克等化学家开创的“传统”钯催化交叉偶联反应进行比较。虽然这些反应为交叉偶联定义提供了基础，但它们并没有定义这种类型的转化，这种转化早在近20年前就由林斯特德首次描述。我们主张拓宽交叉偶联的定义，而不是修改和划分现代转化反应，以便将它们归类为合成定义或机理定义，从而鼓励围绕探索新型反应活性和切断方式展开讨论。除了论证一个通用的交叉偶联定义外，我们还列举了一些打破先前交叉偶联定义模式的具体反应实例。我们相信这一观点将激发关于交叉偶联反应内涵的讨论，进而推动该领域未来的发展。
