Kong Jingyin, Li Songjun, Li Yingting, Chen Min
Department of Prenatal Diagnosis and Fetal Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Department of Reproduction Medical Center, The Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
Front Cell Dev Biol. 2023 Jan 13;11:1034455. doi: 10.3389/fcell.2023.1034455. eCollection 2023.
Placenta-mediated pregnancy complications (PMPCs), including preeclampsia (PE), fetal growth restriction (FGR), and recurrent spontaneous abortion (RSA), occur in approximately 5% of pregnancies and are caused by abnormal placenta development. The development of effective therapies for PMPCs is still challenging due to the complicated pathogenesis, such as disrupted vascular homeostasis and subsequent abnormal placentation. Synthetic drugs have been recommended for treating PMPCs; however, they tend to cause adverse reactions in the mother and fetus. () has potential effects on PMPCs owing to its advantages in treating cardiovascular disorders. and its active compounds could attenuate the symptoms of PMPCs through anticoagulation, vasodilation, antioxidation, and endothelial protection. Thus, in this review, we summarize the literature and provide comprehensive insights on and its phytochemical constituents, pharmacological activities, and on PMPCs, which would be valuable to explore promising drugs.
胎盘介导的妊娠并发症（PMPCs），包括子痫前期（PE）、胎儿生长受限（FGR）和复发性自然流产（RSA），约5%的妊娠会出现，且由胎盘发育异常引起。由于发病机制复杂，如血管稳态破坏及随后的胎盘形成异常，开发有效的PMPCs治疗方法仍具有挑战性。合成药物已被推荐用于治疗PMPCs；然而，它们往往会在母亲和胎儿身上引起不良反应。（）因其在治疗心血管疾病方面的优势而对PMPCs具有潜在作用。其活性化合物可通过抗凝、血管舒张、抗氧化和内皮保护减轻PMPCs的症状。因此，在本综述中，我们总结了相关文献，并对（）及其植物化学成分、药理活性以及PMPCs提供了全面的见解，这对于探索有前景的药物具有重要价值。
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