Chen Mengting, Jin Yafang, Cao Xiaohui
Department of Obstetrics, Women's Hospital of Jiangnan University, Wuxi Maternity and Child Health Care Hospital, No. 48, Samuel Lane, Liangxi District, Wuxi 214002, China.
Biol Reprod. 2025 Jul 13;113(1):19-33. doi: 10.1093/biolre/ioaf071.
Preeclampsia (PE), a common obstetric complication during pregnancy, has a global prevalence of 5-8%, and it is one of the leading causes of adverse maternal and fetal outcomes, which has a lack of effective treatment other than termination of pregnancy. Endoplasmic reticulum stress (ERS) is a self-stress response of cells to alleviate misfolded and unfolded protein aggregation and calcium ion homeostasis disorders in the endoplasmic reticulum (ER) lumen by activating the unfolded protein response. Many studies have demonstrated a potential link between ERS and PE pathogenesis by mediating genetic susceptibility, placental hypoxia, oxidative stress, metabolic disorders, impaired angiogenesis and function, and inflammatory responses. This article systematically describes the ERS mechanisms and their association with the pathological progression of PE. It also emphasizes that ERS can be a potential therapeutic target for PE clinical management.
子痫前期（PE）是孕期常见的产科并发症，全球患病率为5%-8%，是孕产妇和胎儿不良结局的主要原因之一，除终止妊娠外缺乏有效的治疗方法。内质网应激（ERS）是细胞的一种自我应激反应，通过激活未折叠蛋白反应来缓解内质网（ER）腔内错误折叠和未折叠的蛋白质聚集以及钙离子稳态紊乱。许多研究表明，ERS通过介导遗传易感性、胎盘缺氧、氧化应激、代谢紊乱、血管生成和功能受损以及炎症反应，与PE的发病机制存在潜在联系。本文系统地描述了ERS机制及其与PE病理进展的关联。还强调了ERS可能成为PE临床管理的潜在治疗靶点。
