解锁G-四链体作为对抗新冠病毒的靶点和工具
Unlocking G-Quadruplexes as Targets and Tools against COVID-19.
作者信息
Qin Geng, Zhao Chuanqi, Yang Jie, Wang Zhao, Ren Jinsong, Qu Xiaogang
机构信息
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Science Changchun, Jilin 130022 China.
University of Science and Technology of China Hefei Anhui 230026 China.
出版信息
Chin J Chem. 2022 Dec 30. doi: 10.1002/cjoc.202200486.
The applicability of G-quadruplexes (G4s) as antiviral targets, therapeutic agents and diagnostic tools for coronavirus disease 2019 (COVID-19) is currently being evaluated, which has drawn the extensive attention of the scientific community. During the COVID-19 pandemic, research in this field is rapidly accumulating. In this review, we summarize the latest achievements and breakthroughs in the use of G4s as antiviral targets, therapeutic agents and diagnostic tools for COVID-19, particularly using G4 ligands. Finally, strength and weakness regarding G4s in anti-SARS-CoV-2 field are highlighted for prospective future projects.
G-四链体（G4s）作为2019冠状病毒病（COVID-19）的抗病毒靶点、治疗剂和诊断工具的适用性目前正在评估中，这已引起科学界的广泛关注。在COVID-19大流行期间，该领域的研究正在迅速积累。在这篇综述中，我们总结了将G4s用作COVID-19的抗病毒靶点、治疗剂和诊断工具，特别是使用G4配体方面的最新成果和突破。最后，针对未来的前瞻性项目，强调了G4s在抗严重急性呼吸综合征冠状病毒2（SARS-CoV-2）领域的优势和不足。
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