Ioannou Elina, Oikonomou Stavros, Efthymiou Nikolaos, Constantinou Andria, Delplancke Thibaut, Charisiadis Pantelis, Makris Konstantinos C
Cyprus International Institute of Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus.
Nutrition & Dietetics Department, Limassol General Hospital, State Health Services Organization, Limassol, Cyprus.
iScience. 2022 Dec 22;26(2):105847. doi: 10.1016/j.isci.2022.105847. eCollection 2023 Feb 17.
Tailoring medical models to the right person or risk subgroups delivered at the right time is important in personalized medicine/prevention initiatives. The CIRCA-CHEM randomized 2x2 crossover pilot trial investigated whether the consumption of fruits/vegetables within a time-restricted daily window would affect urinary biomarkers of exposure to neonicotinoids (6-chloronicotinic acid, 6-CN) and pyrethroids (3-phenoxybenzoic acid, 3-PBA) pesticides, a biomarker of oxidative damage (4-hydroxynonenal, 4-HNE) and the associated urinary NMR metabolome. A statistically significant difference (p ) in both creatinine-adjusted 6-CN and 3-PBA levels was observed between the two-time dietary intervention windows (morning vs. evening). In the evening intervention period, pesticides biomarker levels were higher compared to the baseline, whereas in the morning period, pesticide levels remained unchanged. Positive associations were observed between pesticides and 4-HNE suggesting a diurnal chrono-window of pesticide toxicity. The discovery of a chronotoxicity window associated with chrono-disrupted metabolism of food contaminants may find use in personalized medicine initiatives.
在个性化医疗/预防计划中，为合适的人或风险亚组量身定制医疗模式，并在合适的时间提供，这一点很重要。CIRCA-CHEM随机2x2交叉试点试验研究了在每日限时窗口内食用水果/蔬菜是否会影响新烟碱类农药（6-氯烟酸，6-CN）和拟除虫菊酯类农药（3-苯氧基苯甲酸，3-PBA）暴露的尿液生物标志物、氧化损伤生物标志物（4-羟基壬烯醛，4-HNE）以及相关的尿液核磁共振代谢组。在两个饮食干预窗口（早晨与晚上）之间，观察到肌酐校正后的6-CN和3-PBA水平存在统计学显著差异（p）。在晚上的干预期，农药生物标志物水平相对于基线更高，而在早晨期间，农药水平保持不变。在农药与4-HNE之间观察到正相关，表明农药毒性存在昼夜时间窗口。与食物污染物的时间紊乱代谢相关的时间毒性窗口的发现可能会在个性化医疗计划中得到应用。
