Abdallah Bushra, Arif Mariah, Al-Malki Maryam, Hourani Razan, Al-Maadeed Tamader, Khodr Nidal, Al-Kuwari Ghaith, Al-Siddiqi Mashael, Kane Tanya, Chivese Tawanda
Department of Population Medicine, College of Medicine, QU Health, Qatar University, Doha, Qatar.
Int J Gen Med. 2023 Jan 21;16:233-242. doi: 10.2147/IJGM.S393284. eCollection 2023.
This research investigated the association between childhood and adulthood tobacco smoking exposure with ulcerative colitis (UC) and Crohn's disease (CD) in Qatar.
In this case-control study, CD and UC cases were matched to controls of the same age and sex. The associations between UC and CD and childhood passive smoking and adulthood active smoking were assessed using conditional multivariable logistic regression.
A total of 89 CD cases, median age of 37 years (IQR 29-47), and 362 UC cases, median age of 35 years (IQR 28-44), and equal numbers of controls were included. After multivariable logistic regression, CD was associated with higher odds of being a current smoker (OR 2.51, 95% CI 0.85-7.37, p=0.095), with weak evidence against the null hypothesis. This association was more pronounced in women, where CD was associated with both adulthood current smoking (OR 42.71, 95% CI, 1.17-1559.57, p=0.041), and childhood smoking exposure (OR 8.23, 95% CI, 1.36-49.66, p=0.021). In males, no associations were observed between CD and the smoking exposures. No associations were observed between UC and both smoking variables.
In Qatar, adulthood tobacco smoking appears to increase the odds of CD. Further, our findings suggest that both childhood and adulthood cigarette smoke exposure may possibly have a detrimental effect on the odds of CD in females but not in males, although further research is needed.
本研究调查了卡塔尔儿童期和成年期吸烟暴露与溃疡性结肠炎（UC）和克罗恩病（CD）之间的关联。
在这项病例对照研究中，CD和UC病例与年龄和性别相同的对照组进行匹配。使用条件多变量逻辑回归评估UC和CD与儿童期被动吸烟和成年期主动吸烟之间的关联。
共纳入89例CD病例，中位年龄37岁（四分位间距29 - 47岁），362例UC病例，中位年龄35岁（四分位间距28 - 44岁），且对照组数量相同。多变量逻辑回归后，CD与当前吸烟者的较高比值比相关（比值比2.51，95%置信区间0.85 - 7.37，p = 0.095），有微弱证据反对原假设。这种关联在女性中更明显，其中CD与成年期当前吸烟（比值比42.71，95%置信区间1.17 - 1559.57，p = 0.041）和儿童期吸烟暴露（比值比8.23，95%置信区间1.36 - 49.66，p = 0.021）均相关。在男性中，未观察到CD与吸烟暴露之间的关联。未观察到UC与两个吸烟变量之间的关联。
在卡塔尔，成年期吸烟似乎会增加患CD的几率。此外，我们的研究结果表明，儿童期和成年期吸烟暴露可能对女性患CD的几率有不利影响，但对男性没有，不过仍需要进一步研究。
