Mosli Mahmoud, Alawadhi Sameer, Hasan Fuad, Abou Rached Antoine, Sanai Faisal, Danese Silvio
Gastroenterologist and Inflammatory Bowel Disease Specialist, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Digestive Disease Unit, Rashid Hospital, Dubai, United Arab Emirates.
Inflamm Intest Dis. 2021 Sep 7;6(3):123-131. doi: 10.1159/000518003. eCollection 2021 Sep.
Despite the recent findings of the rising incidence of inflammatory bowel disease (IBD) in Arab countries, there are limited data on the characteristics of IBD patients and the disease course in the Arab world. This systematic review aimed to investigate the incidence and epidemiology of IBD in the Arab world.
We conducted a systematic literature review that utilized a comprehensive search of PubMed, Cochrane Central, SCOPUS, Google Scholar, and Web of Science from their inception till August 2020. We included cross-sectional, prospective, and retrospective studies that examined the prevalence and/or epidemiological characteristics of IBD in Arab countries.
A total of 16 studies that examined IBD in Saudi Arabia, Egypt, Kuwait, the United Arab Emirates, Bahrain, Lebanon, and Oman were included. Generally, the included studies covered the period from the early 1990s to the late 2010s. A total of 1,627 ulcerative colitis (UC) patients and 1,588 Crohn's disease (CD) patients were included in this systematic review. The mean age at diagnosis ranged from 24.13 to 43.6 years in adult cases and from 4.5 to 16 years in pediatric cases. In most of the included studies, the majority of patients were male. The quantitative analysis revealed a pooled incidence rate of 2.33 (95% confidence interval [CI] 1.2-3.4) per 100,000 persons per year for UC in the Arab world. Likewise, the pooled incidence rate for CD in the Arab world was 1.46 (95% CI 1.03-1.89) per 100,000 persons per year.
There is a growing incidence of IBD in the Arab world, while IBD patients from Arab countries may present with some different characteristics, compared to their counterparts in Europe.
尽管近期有研究发现阿拉伯国家炎症性肠病（IBD）的发病率呈上升趋势，但关于阿拉伯世界IBD患者的特征及疾病进程的数据有限。本系统评价旨在调查阿拉伯世界IBD的发病率及流行病学情况。
我们进行了一项系统的文献综述，对PubMed、Cochrane Central、SCOPUS、谷歌学术和科学网从创建至2020年8月进行了全面检索。我们纳入了横断面研究、前瞻性研究和回顾性研究，这些研究调查了阿拉伯国家IBD的患病率和/或流行病学特征。
共纳入了16项在沙特阿拉伯、埃及、科威特、阿拉伯联合酋长国、巴林、黎巴嫩和阿曼开展的关于IBD的研究。总体而言，纳入的研究涵盖了20世纪90年代初至2010年代末的时间段。本系统评价共纳入了1627例溃疡性结肠炎（UC）患者和1588例克罗恩病（CD）患者。成人病例的诊断平均年龄在24.13至43.6岁之间，儿科病例的诊断平均年龄在4.5至16岁之间。在大多数纳入研究中，大多数患者为男性。定量分析显示，阿拉伯世界UC的合并发病率为每年每10万人2.33例（95%置信区间[CI]1.2 - 3.4）。同样，阿拉伯世界CD的合并发病率为每年每10万人1.46例（95%CI 1.03 - 1.89）。
阿拉伯世界IBD的发病率在不断上升，与欧洲的IBD患者相比，来自阿拉伯国家的IBD患者可能具有一些不同的特征。
