Hara S, Ichikawa T, Akimoto S, Wakisaka M, Shimazaki J
Department of Urology, School of Medicine, Chiba University, Japan.
Prostate. 1987;11(2):107-15. doi: 10.1002/pros.2990110202.
Effects of chemotherapy and endocrine therapy applied individually or in combination on growth of an androgen-stimulated mouse tumor, Shionogi carcinoma 115 (SC 115), were examined. In the present study cyclophosphamide and castration were used as chemo- and endocrine therapy, respectively, and simultaneous combination of these two treatments was found to be the most effective in inhibiting tumor growth. When comparing the effect of castration alone with that of injection of cyclophosphamide alone, the former retarded the tumor growth more efficiently, but relapse occurred in both instances. Injection of cyclophosphamide to the relapsed tumor after castration caused a marked effect when compared with the effect of the drug on the untreated or the chemotherapy-relapsed tumors. Castration caused a retardation of growth in the chemotherapy-relapsed tumor, but the survival period was shorter than that observed in the mice that received castration followed by injection of cyclophosphamide. From these results, it was concluded that castration followed by chemotherapy was the preferred order among sequential treatments for the SC 115; however, the optimal treatment was produced by simultaneous combination of chemotherapy plus castration.
研究了单独或联合应用化疗和内分泌疗法对雄激素刺激的小鼠肿瘤——史氏癌115（SC 115）生长的影响。在本研究中，分别使用环磷酰胺和去势作为化疗和内分泌疗法，发现这两种治疗方法同时联合使用对抑制肿瘤生长最为有效。当比较单独去势与单独注射环磷酰胺的效果时，前者更有效地抑制了肿瘤生长，但两种情况下均出现复发。与该药物对未治疗或化疗复发肿瘤的效果相比，去势后对复发肿瘤注射环磷酰胺产生了显著效果。去势使化疗复发肿瘤的生长减缓，但生存期比接受去势后注射环磷酰胺的小鼠短。从这些结果得出结论，对于SC 115的序贯治疗，去势后化疗是首选顺序；然而，最佳治疗是化疗加去势同时联合应用。
