CD74在心血管疾病中的作用。
The role of CD74 in cardiovascular disease.
作者信息
Li Qiu-Lin, Tang Jing, Zhao Ling, Ruze Amanguli, Shan Xue-Feng, Gao Xiao-Ming
机构信息
State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China.
Xinjiang Key Laboratory of Medical Animal Model Research, Ürümqi, China.
出版信息
Front Cardiovasc Med. 2023 Jan 12;9:1049143. doi: 10.3389/fcvm.2022.1049143. eCollection 2022.
Leukocyte differentiation antigen 74 (CD74), also known as invariant chain, is a molecular chaperone of major histocompatibility complex class II (MHC II) molecules involved in antigen presentation. CD74 has recently been shown to be a receptor for the macrophage migration inhibitory factor family proteins (MIF/MIF2). Many studies have revealed that CD74 plays an important role in cardiovascular disease. In this review, we summarize the structure and main functions of CD74 and then focus on the recent research progress on the role of CD74 in cardiovascular diseases. In addition, we also discuss potential treatment strategies that target CD74. Our systematic review of the role of CD74 in cardiovascular disease will fill some knowledge gaps in the field.
白细胞分化抗原74（CD74），也称为恒定链，是参与抗原呈递的主要组织相容性复合体II类（MHC II）分子的分子伴侣。最近有研究表明，CD74是巨噬细胞迁移抑制因子家族蛋白（MIF/MIF2）的受体。许多研究已经揭示，CD74在心血管疾病中起重要作用。在这篇综述中，我们总结了CD74的结构和主要功能，然后重点阐述了CD74在心血管疾病中作用的最新研究进展。此外，我们还讨论了以CD74为靶点的潜在治疗策略。我们对CD74在心血管疾病中作用的系统综述将填补该领域的一些知识空白。
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