Katano Atsuto, Yamashita Hideomi
Radiology, The University of Tokyo Hospital, Tokyo, JPN.
Cureus. 2022 Dec 26;14(12):e32971. doi: 10.7759/cureus.32971. eCollection 2022 Dec.
Aim In advanced gastric cancer, symptoms such as loss of appetite, stomach tightness, occasional pain, vomiting blood, and melena may occur. Palliative radiation therapy may be indicated in such cases. This study aimed to investigate the clinical outcomes of palliative radiotherapy in patients with advanced-stage gastric carcinoma. Methods From April 2018 to October 2022, consecutive patients with non-resected advanced gastric cancer who received radiation therapy for palliation of symptoms were included. Results A total of 23 patients with advanced-stage gastric carcinoma were analyzed in this study. Twelve male and 11 female patients were included. The median overall survival period was 3.9 months (95% confidence interval: 1.0-8.7 months). Sixteen patients required erythrocyte transfusion before radiotherapy; for 13 patients (83%), the required units of erythrocyte transfusion decreased after palliative radiotherapy. The mean erythrocyte transfusion units significantly decreased from 4.2 (standard deviation [SD]: 4.3) to 1.7 (SD: 3.6) (p = 0.02). No adverse events of grade ≥3 were observed in this study population. Conclusion Palliative radiation therapy for advanced gastric cancer yielded a good response rate and can be a useful treatment option.
目的 在晚期胃癌中，可能会出现食欲不振、胃部紧绷、偶尔疼痛、吐血和黑便等症状。在此类情况下，可能需要进行姑息性放射治疗。本研究旨在调查晚期胃癌患者姑息性放疗的临床疗效。方法 纳入2018年4月至2022年10月期间连续接受放疗以缓解症状的未切除晚期胃癌患者。结果 本研究共分析了23例晚期胃癌患者。其中男性12例，女性11例。中位总生存期为3.9个月（95%置信区间：1.0 - 8.7个月）。16例患者在放疗前需要输血；13例患者（83%）在姑息性放疗后所需输血量减少。平均输血量从4.2（标准差[SD]：4.3）显著降至1.7（SD：3.6）（p = 0.02）。本研究人群未观察到≥3级不良事件。结论 晚期胃癌的姑息性放射治疗有效率良好，可作为一种有用的治疗选择。
