Cai Shuyan, Zheng Jianwei, Song Huimin, Wu Haoliang, Cai Wang
Department of General Surgery, Beijing Chaoyang Hospital Affiliated with Capital Medical University, Beijing, China.
Front Genet. 2023 Jan 12;13:1095338. doi: 10.3389/fgene.2022.1095338. eCollection 2022.
To investigate the levels of serum transforming growth factor-β 1 (TGF-β1), Matrix metalloproteinase-9 (MMP-9) and Interleukin-1 β (IL-1 β) in breast cancer (BC), and analyzing their relationship with pathological features and prognosis. Retrospective analysis of 86 subjects with BC (BC subgroup) and another 50 healthy subjects (control subgroup) during the same period were included. The clinical data were collected. In this research, in BC subgroup, The levels of serum TGF- β 1, MMP-9 and IL-1 β were significantly higher than those in control subgroup. The levels of TGF- β 1 and MMP-9 in serum of BC subjects was correlated with clinical stage, histological grade, lymph node metastasis and molecular classification, but not with age, tumor size and menopausal status. The level of serum IL-1 β was related to tumor size, clinical stage, histological grade and lymph node metastasis. Multivariate Logistic regression analysis showed that the high level of serum TGF- β1 and MMP-9 was independent risk factors for BC. High level of serum IL-1 β was not an independent risk factor for BC. The 3-year disease-free survival rate in high TGF- β1 subgroup and high MMP-9 subgroup was significantly lower than that in low TGF- β 1 subgroup and low MMP- 9 subgroup. To conclude, serum TGF- β 1, MMP-9 and IL-1β are highly expressed in BC, and the subjects with elevated serum levels of TGF- β 1 and MMP-9 suggests poor prognosis.
探讨乳腺癌（BC）患者血清转化生长因子-β1（TGF-β1）、基质金属蛋白酶-9（MMP-9）和白细胞介素-1β（IL-1β）水平，并分析其与病理特征及预后的关系。纳入86例BC患者（BC亚组）及同期50例健康受试者（对照组亚组）进行回顾性分析。收集临床资料。本研究中，BC亚组血清TGF-β1、MMP-9和IL-1β水平显著高于对照组亚组。BC患者血清中TGF-β1和MMP-9水平与临床分期、组织学分级、淋巴结转移及分子分型相关，但与年龄、肿瘤大小和绝经状态无关。血清IL-1β水平与肿瘤大小、临床分期、组织学分级和淋巴结转移有关。多因素Logistic回归分析显示，血清TGF-β1和MMP-9高水平是BC的独立危险因素。血清IL-1β高水平不是BC的独立危险因素。高TGF-β1亚组和高MMP-9亚组的3年无病生存率显著低于低TGF-β1亚组和低MMP-9亚组。综上所述，血清TGF-β1、MMP-9和IL-1β在BC中高表达，血清TGF-β1和MMP-9水平升高的患者预后较差。
