MTFR2在肝细胞癌中塑造免疫微环境屏障。

MTFR2 shapes a barrier of immune microenvironment in hepatocellular carcinoma.

作者信息

Huang Qiaoqiao, Han Ying, Shen Edward, Feng Ziyang, Peng Yinghui, Gao Le, Gao Yan, Liu Yongting, Li Wei, Liu Ping, Chen Yihong, Guo Cao, Zeng Shan, Cai Changjing, Shen Hong

机构信息

Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

出版信息

iScience. 2022 Sep 10;26(1):105095. doi: 10.1016/j.isci.2022.105095. eCollection 2023 Jan 20.

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death in the world. Mitochondrial fission regulator 2 (MTFR2) is involved in the development of various cancers. However, the roles of MTFR2 in HCC remain unknown. In this study, we conducted a comprehensive analysis of MTFR2 in HCC, which was generated from integrative MTFR2 analyses of eight HCC cell lines, and three datasets (public dataset, real-world dataset, and immunotherapy dataset) derived from bulk HCC tissues, survival, and immunotherapy data. We demonstrated that the expression level of MTFR2 is upregulated in HCC, leading to poor prognosis. MTFR2 is positively correlated with the level of immune cell infiltration, multiple immune checkpoints and immunotherapy response prediction pathways, and acts as an important role in cancer-immunity cycle. In conclusion, our work indicates that MTFR2 can shape a barrier of immune microenvironment and result in poor prognosis in hepatocellular carcinoma, but the immune barrier may be broken by immunotherapy.

肝细胞癌（HCC）是全球癌症相关死亡的主要原因。线粒体裂变调节因子2（MTFR2）参与多种癌症的发展。然而，MTFR2在HCC中的作用仍不清楚。在本研究中，我们对HCC中的MTFR2进行了全面分析，该分析来自对八个HCC细胞系以及从大量HCC组织、生存和免疫治疗数据得出的三个数据集（公共数据集、真实世界数据集和免疫治疗数据集）的综合MTFR2分析。我们证明MTFR2的表达水平在HCC中上调，导致预后不良。MTFR2与免疫细胞浸润水平、多个免疫检查点和免疫治疗反应预测途径呈正相关，并在癌症免疫循环中起重要作用。总之，我们的工作表明MTFR2可形成免疫微环境屏障并导致肝细胞癌预后不良，但免疫屏障可能会被免疫治疗打破。