Cai Changjing, Liu Yiting, Lu Ruohuang, Fan Xudong, Zeng Shan, Gan Pingping
Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Exp Hematol Oncol. 2025 Jun 13;14(1):83. doi: 10.1186/s40164-025-00676-x.
Platelets play a critical role in tumor immunity, particularly in promoting cancer progression. Numerous studies suggest that platelets could serve as a novel target for cancer immunotherapy, however, no comprehensive reviews have yet summarized and discussed this potential. Our review provides an in-depth discussion of the roles and mechanisms of platelets within both the immunosuppressive tumor microenvironment and the anti-tumor immune microenvironment. Additionally, we summarize the key therapeutic targets and approaches for clinical translation. This work offers essential insights for reprogramming platelets to shift their function from tumor promotion to tumor suppression, providing a foundation for the development of novel immunotherapeutic strategies and related research.
血小板在肿瘤免疫中发挥着关键作用，尤其是在促进癌症进展方面。众多研究表明，血小板可作为癌症免疫治疗的新靶点，然而，尚无全面综述对这一潜力进行总结和讨论。我们的综述深入探讨了血小板在免疫抑制性肿瘤微环境和抗肿瘤免疫微环境中的作用及机制。此外，我们总结了临床转化的关键治疗靶点和方法。这项工作为重新编程血小板以将其功能从促进肿瘤转变为抑制肿瘤提供了重要见解，为新型免疫治疗策略及相关研究的发展奠定了基础。
