绒毛取样样本中染色体异常的产前诊断：采用改良直接法提高成功率。

Prenatal diagnosis of chromosomal abnormalities from chorionic biopsy samples: improved success rate using a modified direct method.

作者信息

Metaxotou C, Antsaklis A, Panagiotopoulou P, Benetou M, Mavrou A, Matsaniotis N

机构信息

First Department of Pediatrics, Athens University, Greece.

出版信息

Prenat Diagn. 1987 Sep;7(7):461-9. doi: 10.1002/pd.1970070702.

DOI:10.1002/pd.1970070702

PMID:3671333

Abstract

Several methods for fetal chromosome analysis using chorionic biopsy samples were compared. A modified direct method for culturing villi was considered to be the method of choice and details are presented of 186 pregnancies tested prenatally. The success rate in obtaining a fetal karyotype with the direct method was 93 per cent. The fetal loss rate in the prenatal series was 4.3 per cent and congenital abnormalities in the babies already born did not differ from the expected incidence.

摘要

比较了几种使用绒毛膜活检样本进行胎儿染色体分析的方法。一种改良的直接培养绒毛的方法被认为是首选方法，并介绍了186例产前检测妊娠的详细情况。直接法获得胎儿核型的成功率为93%。产前系列中的胎儿丢失率为4.3%，已出生婴儿的先天性异常发生率与预期发病率无差异。