Wu Xinglong, Di Lianjun, Li Chengfang, Zhang Suyuan, Tan Na, Huang Jiajia, Tuo Biguang
Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Front Oncol. 2023 Jan 11;12:1016447. doi: 10.3389/fonc.2022.1016447. eCollection 2022.
Hepatoid adenocarcinoma of the stomach (HAS) is a rare subtype of gastric cancer with poor prognosis, and its clinicopathological features are not well understood, so the pathology from the clinical biopsy is easily misdiagnosed, especially for special or atypical HAS. We present an extremely rare early HAS with signet ring cell carcinoma and evaluate its clinicopathological features.
A 51-year-old female patient of Chinese Han ethnicity with upper abdominal pain for 5 years and worsened abdominal pain for 1 month was admitted to our hospital. Esophagogastroduodenoscopy showed a submucosal tumor-like elevated lesion with central depression in the greater curvature of the junction between the antrum and body. Histopathological examination from the biopsy revealed medium-low-differentiation adenocarcinoma with signet ring cell carcinoma. Radical gastrectomy was performed, and the final diagnosis was early HAS with signet ring cell carcinoma.
HAS with signet ring cell carcinoma is a special type of HAS and extremely rare. It is first presented for this extremely rare type of HAS, which contributes to strengthen the understanding for the clinicopathological characteristics of HAS and especially promote early detection of HAS.
胃肝样腺癌（HAS）是一种预后较差的罕见胃癌亚型，其临床病理特征尚未完全明确，因此临床活检病理易被误诊，尤其是特殊或非典型的HAS。我们报告一例极其罕见的伴有印戒细胞癌的早期HAS，并评估其临床病理特征。
一名51岁中国汉族女性患者，上腹部疼痛5年，腹痛加重1个月，入住我院。食管胃十二指肠镜检查显示，胃窦与胃体交界处大弯侧有一个黏膜下肿瘤样隆起病变，中央凹陷。活检组织病理学检查显示中低分化腺癌伴印戒细胞癌。行根治性胃切除术，最终诊断为伴有印戒细胞癌的早期HAS。
伴有印戒细胞癌的HAS是一种特殊类型的HAS，极其罕见。首次报道这种极其罕见的HAS类型，有助于加强对HAS临床病理特征的认识，特别是促进HAS的早期发现。
