Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Institute of Nuclear Medicine, Fudan University, Shanghai 200032, China.
Contrast Media Mol Imaging. 2023 Jan 18;2023:4722499. doi: 10.1155/2023/4722499. eCollection 2023.
To investigate the biodistribution and kinetic constants of Ga-DOTATATE in normal organs through dynamic total-body positron emission tomography/computed tomography (PET/CT).
Seven patients who experienced endoscopic resection of gastric neuroendocrine tumor were enrolled. Dynamic total-body PET/CT scans over 60 min were performed. Time-activity curves were obtained by drawing regions of interest in normal organs. Rate constants, including , , , and vB, were computed using a two-tissue compartment model. Factor analysis was used to compare the rate constants among subjects and regions. Hierarchical cluster analysis was performed to identify organs with similar kinetic characteristics.
The highest uptake of Ga-DOTATATE was observed in the spleen followed by kidneys, adrenals, liver, pituitary gland, pancreas head, prostate, pancreas body, and thyroid, parotid, and submandibular glands. Low background level of Ga-DOTATATE uptake was observed in the nasal mucosa, bone, blood pool, and cerebrum. In addition, the uptake in the pancreas head was noted to be higher than the pancreas body ( < 0.001) on the basis of each time point of dynamic PET. There were differences of rate constants among different organs. The mean ranged from 0.0507 min in the left nasal mucosa to 1.21 min in the left kidney, and mean ranged from 0.0174 min in the spleen to 4.4487 min in the left cerebrum. The mean ranged from 0.0563 min in the right cerebrum to 4.6309 min in the left adrenal, and mean vB ranged from 0.0001 in the left cerebrum to 0.2489 in the right adrenal. However, none of the rate constants was significantly different among subjects or among different sites within a single organ. Three groups of organs with similar kinetic characteristics were identified: (1) cerebrum; (2) pituitary gland, liver, adrenal, and prostate; and (3) nasal mucosa, parotid and submandibular glands, thyroid, spleen, pancreas, kidney, and bone.
Uptake and clearance of Ga-DOTATATE, in terms of kinetic constants, were different in different organs. The kinetic parameters of Ga-DOTATATE in different organs provide a reference for future dynamic PET imaging.
通过动态全身正电子发射断层扫描/计算机断层扫描（PET/CT）研究 Ga-DOTATATE 在正常器官中的分布和动力学常数。
纳入 7 例行内镜下胃神经内分泌肿瘤切除术的患者。进行 60 分钟的全身动态 PET/CT 扫描。通过在正常器官中绘制感兴趣区获得时间-活性曲线。使用双组织室模型计算速率常数，包括、、、和 vB。因子分析用于比较受试者和区域之间的速率常数。进行层次聚类分析以识别具有相似动力学特征的器官。
Ga-DOTATATE 的摄取最高的器官是脾脏，其次是肾脏、肾上腺、肝脏、垂体、胰头、前列腺、胰体和甲状腺、腮腺和颌下腺。鼻腔黏膜、骨骼、血池和大脑的 Ga-DOTATATE 摄取水平较低。此外，基于动态 PET 的每个时间点，胰头的摄取量均高于胰体（<0.001）。不同器官的速率常数存在差异。平均 范围从左侧鼻腔黏膜的 0.0507 分钟到左侧肾脏的 1.21 分钟，平均 范围从脾脏的 0.0174 分钟到左侧大脑的 4.4487 分钟。平均 范围从右侧大脑的 0.0563 分钟到左侧肾上腺的 4.6309 分钟，平均 vB 范围从左侧大脑的 0.0001 到右侧肾上腺的 0.2489。然而，在受试者之间或单个器官内的不同部位之间，没有一个速率常数具有统计学差异。确定了三组具有相似动力学特征的器官：（1）大脑；（2）垂体、肝脏、肾上腺和前列腺；（3）鼻腔黏膜、腮腺和颌下腺、甲状腺、脾脏、胰腺、肾脏和骨骼。
根据动力学常数，Ga-DOTATATE 在不同器官中的摄取和清除不同。不同器官中 Ga-DOTATATE 的动力学参数为未来的动态 PET 成像提供了参考。
