Prodrug Based on Ionic Liquids for Dual-Triggered Release of Thiabendazole.

The application of triggered release pesticides can provide active ingredient release at required environmental conditions, reduce environmental problems, and toxicity to nontarget organisms. In this work, a novel prodrug that responds to water and enzymes as release triggers for thiabendazole was prepared. The release behaviors under different conditions, bioactivity against , and acute toxicity to of prodrugs were investigated. The results showed that the prodrug had remarkable water- and enzyme-triggered release properties, and the correlation coefficients ( ) fitted by the Weibull model were all >0.99. Meanwhile, the prodrug showed improved antifungal efficacy against and reduced toxicity to . Overall, the prodrug developed offers an efficient way to triggered release pesticides, control fungal, and reduce the risk of harm to aquatic organisms.