Zhang Wenbing, Guo Yan, Yang Jiale, Tang Gang, Zhang Jian, Cao Yongsong
College of Horticulture and Plant Protection, Inner Mongolia Agricultural University, Hohhot010018, China.
College of Plant Protection, China Agricultural University, Beijing100094, China.
ACS Omega. 2023 Jan 9;8(3):3484-3492. doi: 10.1021/acsomega.2c07511. eCollection 2023 Jan 24.
The application of triggered release pesticides can provide active ingredient release at required environmental conditions, reduce environmental problems, and toxicity to nontarget organisms. In this work, a novel prodrug that responds to water and enzymes as release triggers for thiabendazole was prepared. The release behaviors under different conditions, bioactivity against , and acute toxicity to of prodrugs were investigated. The results showed that the prodrug had remarkable water- and enzyme-triggered release properties, and the correlation coefficients ( ) fitted by the Weibull model were all >0.99. Meanwhile, the prodrug showed improved antifungal efficacy against and reduced toxicity to . Overall, the prodrug developed offers an efficient way to triggered release pesticides, control fungal, and reduce the risk of harm to aquatic organisms.
触发释放型农药的应用能够在所需的环境条件下实现活性成分的释放，减少环境问题以及对非靶标生物的毒性。在本研究中，制备了一种新型前药，其以水和酶作为噻苯达唑的释放触发剂。研究了前药在不同条件下的释放行为、对[具体生物名称1]的生物活性以及对[具体生物名称2]的急性毒性。结果表明，该前药具有显著的水触发和酶触发释放特性，由威布尔模型拟合得到的相关系数（[具体系数符号]）均>0.99。同时，该前药对[具体生物名称1]显示出提高的抗真菌效果，对[具体生物名称2]的毒性降低。总体而言，所开发的前药为触发释放型农药、控制真菌以及降低对水生生物的危害风险提供了一种有效途径。
