Xu Lei, Zhang Zhiqiang, Jorgensen Adam M, Yang Yuan, Jin Qianheng, Zhang Guangliang, Cao Gaobiao, Fu Yi, Zhao Weixin, Ju Jihui, Hou Ruixing
Suzhou Medical College of Soochow University, Suzhou, 215123, China.
Department of Hand Surgery, Suzhou Ruihua Orthopaedic Hospital, Suzhou, 215104, China.
Mater Today Bio. 2023 Jan 14;18:100550. doi: 10.1016/j.mtbio.2023.100550. eCollection 2023 Feb.
Clinical settings often face significant obstacles in treating large acute wounds. The alternative of therapeutic approach is needed urgently. Hydrogels derived from natural or synthetic materials may be designed to perform a variety of functions for promoting wound healing. Herein, a 3D bioprinted hydrogel patch is designed for accelerating acute wound healing, which is fabricated with methacryloyl-substituted gelatin (GelMA) and silk fibroin (SilMA) dual-cross-linked by ultraviolet (UV) light. The GelMA with added silk fibroin (GelSilMA) shows improved biodegradation and mechanical properties. Furthermore, SilMA hydrogel can maintain a moisturized healing environment in wound area persistently with adequate degradation capacity. In vivo, GelSilMA (G-S) hydrogel can help to speed wound closure by the improved microenvironment for epidermal tissue regeneration and endogenous collagen generation accordingly. In summary, the G-S hydrogel patch can accelerate acute wound healing efficiently in a relatively simple and inexpensive manner.
临床环境在治疗大面积急性伤口时常常面临重大障碍。迫切需要替代的治疗方法。源自天然或合成材料的水凝胶可被设计用于执行促进伤口愈合的多种功能。在此，设计了一种用于加速急性伤口愈合的3D生物打印水凝胶贴片，它由通过紫外线（UV）光双重交联的甲基丙烯酰基取代明胶（GelMA）和丝素蛋白（SilMA）制成。添加了丝素蛋白的GelMA（GelSilMA）显示出改善的生物降解性和机械性能。此外，SilMA水凝胶能够以足够的降解能力在伤口区域持续维持湿润的愈合环境。在体内，GelSilMA（G-S）水凝胶可通过改善表皮组织再生的微环境以及相应地促进内源性胶原蛋白生成来帮助加速伤口闭合。总之，G-S水凝胶贴片能够以相对简单且廉价的方式有效加速急性伤口愈合。
