Mohammadi Hamidreza, Shirmohammadi Adileh, Babaloo Amirreza, Roshangar Leila, Torab Zeinab, Mojtahedinia Mehdi
Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Histology and Embryology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
J Adv Periodontol Implant Dent. 2022 Oct 26;14(2):62-68. doi: 10.34172/japid.2022.015. eCollection 2022.
Bone deficiency in different areas is problematic in implant placement. Changes in histological, histomorphometric, and radiographic properties of hard tissues in the implant placement area affect many parameters of implant success. Autologous conditioned serum (ACS) is a blood product with high levels of IL1- receptor antagonists. Augmentation surgeries are required in many cases because implant placement in the edentulous areas requires a sufficient amount of bone. Therefore, this study radiographically evaluated the effect of autologous conditioned serum after horizontal bone augmentation. In this prospective RCT, 21 patients eligible patients were evaluated. The patient underwent horizontal ridge augmentation surgery in the area. The ACS-impregnated graft was in direct con-tact with the bone. The control side underwent the same surgical protocol without using ACS. Four months after surgery, a CBCT radiograph was taken, and radiographic changes in the two areas were calculated using the differences in the amount of bone formed in the horizontal dimension as well as the Hounsfield unit (HU). The data were reported using descriptive statistical methods, including means (standard deviations) and frequencies (percentages). According to the results of the Kolmog-orov-Smirnov test, the data had a normal distribution (P>0.05); therefore, paired t-test was used to compare the means of the parameters between the two groups. IRadiographic examinations showed that the horizontal dimension of bone before surgery was similar between the two groups. However, after surgery in the ACS group (33.13±6.1), it was significantly higher than in the control group (62.1±86.4) (P>0.05). Also, the rate of horizontal dimension increase (the difference before and after surgery) in the ACS group was significantly higher than in the control group. Bone density before surgery was similar between the two groups. However, after surgery, there was a significant increase in the ACS group (75.56±330.42 HUs) compared to the control group (38.35±292.38 HUs) (P>0.05). Also, the rate of density increase (the difference before and after surgery) in the ACS group was significantly higher than in the control group. Radiographic evaluations of hard tissues showed a significant increase in the horizontal dimension of bone and density of newly formed bone using ACS compared to the control group.
不同区域的骨量不足在种植体植入中是个问题。种植体植入区域硬组织的组织学、组织形态计量学和影像学特性的变化会影响种植体成功的许多参数。自体条件血清（ACS）是一种含有高水平白细胞介素-1受体拮抗剂的血液制品。在许多情况下需要进行植骨手术，因为在无牙区植入种植体需要足够的骨量。因此，本研究通过影像学评估了水平骨增量后自体条件血清的效果。在这项前瞻性随机对照试验中，对21例符合条件的患者进行了评估。患者在该区域接受了水平牙槽嵴增量手术。浸渍ACS的移植物与骨直接接触。对照组在不使用ACS的情况下采用相同的手术方案。术后4个月，拍摄锥形束CT（CBCT）X线片，并利用水平方向骨形成量以及亨氏单位（HU）的差异计算两个区域的影像学变化。数据采用描述性统计方法报告，包括均值（标准差）和频率（百分比）。根据柯尔莫哥洛夫-斯米尔诺夫检验结果，数据呈正态分布（P>0.05）；因此，采用配对t检验比较两组参数的均值。影像学检查显示，两组术前骨的水平尺寸相似。然而，术后ACS组（33.13±6.1）明显高于对照组（62.1±86.4）（P>0.05）。此外，ACS组水平尺寸增加率（术前和术后的差异）明显高于对照组。两组术前骨密度相似。然而，术后ACS组（7�.56±330.42 HU）与对照组（38.35±292.38 HU）相比有显著增加（P>0.05）。此外，ACS组密度增加率（术前和术后的差异）明显高于对照组。硬组织的影像学评估显示，与对照组相比，使用ACS后骨的水平尺寸和新形成骨的密度显著增加。
