Department of Gastroenterology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China.
Department of Gastroenterology, Peking University Traditional Chinese Medicine Clinical Medical School (Xiyuan), Beijing, China.
Mediators Inflamm. 2023 Jan 20;2023:7590549. doi: 10.1155/2023/7590549. eCollection 2023.
() immunoglobulin G (IgG) seropositivity is prevalent, but its correlation with homocysteine (Hcy), a biomarker of vascular risk events, is unclear. This study is aimed at exploring the correlation of IgG seropositivity and plasma Hcy levels in adults.
Data was obtained from the National Health and Nutrition Examination Survey (NHANES) cycle 1999-2000. Hcy was measured by the Abbott homocysteine assay, and IgG was measured by enzyme-linked immunosorbent assays. The weighted multiple logistic regression analyses with adjustments for potential confounders were conducted. Subgroup analyses stratified by gender, age, and race were performed.
A total of 4029 subjects aged 20-85 years were included. Population prevalence of IgG seropositivity was 44.7% in the overall population with higher prevalence found in those with older age, Mexican Americans, lower education, and lower household income. Levels of plasma Hcy were not elevated in those with IgG seropositivity versus seronegativity ( -0.120 (-0.438, 0.199) = 0.462). This difference was not significant after stratifying by gender and age. However, in the subgroup analyses stratified by race, a negative correlation between seropositivity and plasma Hcy levels was observed in Mexican Americans ( -0.802 (-1.253, -0.352) < 0.001).
IgG seropositivity was not associated with plasma Hcy levels in the general population, but there may be a negative correlation in Mexican Americans. These findings provide new insights to advance the research of the link between plasma Hcy levels and stomach health.
（）免疫球蛋白 G（IgG）血清阳性率较高，但与同型半胱氨酸（Hcy）——一种血管风险事件的生物标志物的相关性尚不清楚。本研究旨在探讨成人 IgG 血清阳性率与血浆 Hcy 水平的相关性。
数据来自 1999-2000 年全国健康和营养调查（NHANES）周期。采用 Abbott 同型半胱氨酸测定法测定 Hcy，酶联免疫吸附试验测定 IgG。采用加权多因素 logistic 回归分析，并对潜在混杂因素进行调整。按性别、年龄和种族进行亚组分析。
共纳入 4029 名 20-85 岁的受试者。总体人群 IgG 血清阳性率为 44.7%，年龄较大、墨西哥裔美国人、受教育程度较低、家庭收入较低的人群阳性率较高。与 IgG 血清阴性相比，阳性者的血浆 Hcy 水平并无升高（-0.120（-0.438，0.199）=0.462）。这种差异在按性别和年龄分层后并不显著。然而，在按种族分层的亚组分析中，墨西哥裔美国人 IgG 血清阳性与血浆 Hcy 水平之间存在负相关（-0.802（-1.253，-0.352）<0.001）。
在一般人群中，IgG 血清阳性与血浆 Hcy 水平无关，但在墨西哥裔美国人中可能存在负相关。这些发现为进一步研究血浆 Hcy 水平与胃部健康之间的关系提供了新的思路。
