Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Department of Clinical Medicine, The Second School of Clinical Medicine, Guangzhou Medical University, Guangzhou, China.
PLoS One. 2024 Aug 15;19(8):e0308686. doi: 10.1371/journal.pone.0308686. eCollection 2024.
This study delves into the association between dietary niacin intake and Helicobacter pylori seropositivity, a topic gaining prominence in academic discourse. However, the precise role of Niacin in the development and progression of Helicobacter pylori seropositivity remains inadequately understood. Thus, this research aims to investigate the connections between H. pylori seropositivity and dietary niacin intake using a nationally representative sample of adults.
A cross-sectional analysis encompassed 4,000 participants from the National Health and Nutrition Examination Survey (NHANES) conducted in the United States between 1999 and 2000, all aged 20 years or older. The study employed the generalized additive model (GAM) and multivariate logistic regression to explore the potential relationship between niacin intake and Helicobacter pylori seropositivity. Subgroup analyses were performed based on gender, age, diabetes, hypertension, and hyperlipemia.
Analyzing cross-sectional data from NHANES 1999-2000 involving individuals aged 20 years and above revealed that out of 4,000 participants, 1,842 tested positive for H. pylori via serology. Multivariate analyses unveiled a significant inverse correlation between niacin intake and H. pylori seropositivity. Adjusted odds ratios (ORs) for dietary niacin intake in quartiles Q2 (13.31-19.26 mg/d), Q3 (19.27-27.42 mg/d), and Q4 (>27.42 mg/d) compared to Q1 (<13.31 mg/d) were 0.83 (95% CI: 0.69-1.01), 0.74 (95% CI: 0.61-0.90), and 0.66 (95% CI: 0.54-0.81), respectively. Moreover, a nonlinear L-shaped relationship (P = 0.022) emerged between niacin intake and H. pylori seropositivity, indicating minimal risk of H. pylori infection at approximately 44.69 mg of niacin per day in the diet.
This study suggests a potential link between increased dietary niacin intake and reduced prevalence of Helicobacter pylori seropositivity. This correlation is bolstered by plausible mechanisms involving immunomodulatory function, mitochondrial dysfunction, and cellular oxidative stress.
本研究深入探讨了饮食烟酸摄入与幽门螺杆菌血清阳性之间的关联，这是学术领域中备受关注的一个话题。然而，烟酸在幽门螺杆菌血清阳性的发展和进展中的具体作用仍未得到充分理解。因此，本研究旨在使用美国全国健康和营养调查（NHANES）1999-2000 年期间年龄在 20 岁及以上的成年人的全国代表性样本，调查 H. pylori 血清阳性与饮食烟酸摄入之间的关系。
采用交叉分析，对美国全国健康和营养调查（NHANES）1999-2000 年期间年龄在 20 岁及以上的 4000 名参与者进行研究。采用广义加性模型（GAM）和多变量逻辑回归分析探讨烟酸摄入与幽门螺杆菌血清阳性之间的潜在关系。并根据性别、年龄、糖尿病、高血压和高脂血症进行了亚组分析。
对 NHANES 1999-2000 年的横断面数据分析显示，在 4000 名参与者中，有 1842 人通过血清学检测呈幽门螺杆菌阳性。多变量分析显示，烟酸摄入与 H. pylori 血清阳性呈显著负相关。与 Q1（<13.31mg/d）相比，Q2（13.31-19.26mg/d）、Q3（19.27-27.42mg/d）和 Q4（>27.42mg/d）的饮食烟酸摄入量的调整优势比（OR）分别为 0.83（95%CI：0.69-1.01）、0.74（95%CI：0.61-0.90）和 0.66（95%CI：0.54-0.81）。此外，烟酸摄入与 H. pylori 血清阳性之间呈非线性 L 型关系（P=0.022），表明饮食中每天摄入约 44.69mg 烟酸时，幽门螺杆菌感染的风险最低。
本研究提示饮食中增加烟酸摄入与降低幽门螺杆菌血清阳性率之间可能存在关联。这种相关性得到了免疫调节功能、线粒体功能障碍和细胞氧化应激等可能机制的支持。
