小儿患者血清骨钙素浓度与能量代谢标志物。系统评价与荟萃分析。
Osteocalcin serum concentrations and markers of energetic metabolism in pediatric patients. Systematic review and metanalysis.
作者信息
Rodríguez-Narciso Silvia, Martínez-Portilla Raigam Jafet, Guzmán-Guzmán Iris Paola, Careaga-Cárdenas Gabriela, Rubio-Navarro Brenda Jazmin, Barba-Gallardo Luis Fernando, Delgadillo-Castañeda Rodolfo, Villafan-Bernal José Rafael
机构信息
Basic Sciences Center, Autonomous University of Aguascalientes, Aguascalientes, Mexico.
Clinical Research Division, Evidence-Based Medicine Department, National Institute of Perinatology, Mexico City, Mexico.
出版信息
Front Pediatr. 2023 Jan 12;10:1075738. doi: 10.3389/fped.2022.1075738. eCollection 2022.
BACKGROUND
Osteocalcin plays a role in glucose metabolism in mice, but its relevance in human energetic metabolism is controversial. Its relationship with markers of energetic metabolism in the pediatric population has not been systematically addressed in infants and adolescents.
OBJECTIVE
This study aims to assess the mean differences between tOC, ucOC, and cOC among healthy children and children with type 1 or type 2 diabetes (T1D or T2D) and the correlation of these bone molecules with metabolic markers.
METHODS
A systematic review and metanalysis were performed following PRISMA criteria to identify relevant observational studies published in English and Spanish using PubMed, Scopus, EBSCO, and Web of Science databases. The risk of bias was assessed using New Castle-Ottawa scale. Effect size measures comprised standardized mean difference (SMD) and Pearson correlations. Heterogeneity and meta-regressions were performed.
RESULTS
The 20 studies included were of high quality and comprised 3,000 pediatric patients who underwent tOC, cOC, or ucOC measurements. Among healthy subjects, there was a positive correlation of ucOC with WC and weight, a positive correlation of tOC with FPG, HDL-c, WC, height, and weight, and a negative correlation between tOC and HbA1c. Among diabetic subjects, a negative correlation of ucOC with HbA1c and glycemia in both T1D and T2D was found and a negative correlation between tOC and HbA1c in T1D but not in T2D. The ucOC concentrations were lower in T2D, T1D, and patients with abnormal glucose status than among controls. The serum concentrations of tOC concentrations were lower among T1D than in controls. The patient's age, altitude, and HbA1c influenced the levels of serum tOC.
CONCLUSION
Osteocalcin is involved in energy metabolism in pediatric subjects because it is consistently related to metabolic and anthropometric parameters.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/prospero/, identifier: CRD42019138283.
背景
骨钙素在小鼠的葡萄糖代谢中发挥作用，但其在人类能量代谢中的相关性存在争议。在婴儿和青少年中，其与儿科人群能量代谢标志物的关系尚未得到系统研究。
目的
本研究旨在评估健康儿童与1型或2型糖尿病（T1D或T2D）患儿之间总骨钙素（tOC）、未羧化骨钙素（ucOC）和羧化骨钙素（cOC）的平均差异，以及这些骨分子与代谢标志物的相关性。
方法
按照PRISMA标准进行系统评价和荟萃分析，以识别使用PubMed、Scopus、EBSCO和Web of Science数据库发表的英文和西班牙文相关观察性研究。使用纽卡斯尔-渥太华量表评估偏倚风险。效应量测量包括标准化均数差（SMD）和Pearson相关性。进行了异质性和meta回归分析。
结果
纳入的20项研究质量较高，共包括3000例接受tOC、cOC或ucOC测量的儿科患者。在健康受试者中，ucOC与腰围（WC）和体重呈正相关，tOC与空腹血糖（FPG）、高密度脂蛋白胆固醇（HDL-c）、WC、身高和体重呈正相关，tOC与糖化血红蛋白（HbA1c）呈负相关。在糖尿病受试者中，发现ucOC在T1D和T2D中均与HbA1c和血糖呈负相关，tOC在T1D中与HbA1c呈负相关，而在T2D中无此相关性。T2D、T1D和血糖异常患者的ucOC浓度低于对照组。T1D患者的血清tOC浓度低于对照组。患者的年龄、海拔和HbA1c影响血清tOC水平。
结论
骨钙素参与儿科受试者的能量代谢，因为它与代谢和人体测量参数始终相关。
系统评价注册
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