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亲水性基质型乙酰水杨酸缓释片的制备

[Preparations of acetylsalicylic acid sustained-release tablets on hydrophilic matrix forms].

作者信息

Süss W, Bruder K

机构信息

Pharmazeutisches Zentrum Oschatz, Klinikapotheke Hubertusburg, Wermsdorf.

出版信息

Pharmazie. 1987 Jul;42(7):457-8.

PMID:3671471
Abstract

The aim of this study was to prepare a tablet with acetylsalicylic acid based on hydrophilic matrix form by means of polyvinyl alcohol. The liberation was carried out with the column dissolution-rate method. In contrast to other studies, the percentage of the cumulative liberation is decreased by increasing the drug concentration. Acetylsalicylic acid caused a decrease of the wetting and the rate of swelling.

摘要

本研究的目的是通过聚乙烯醇制备基于亲水基质形式的阿司匹林片剂。采用柱溶出速率法进行释放研究。与其他研究不同的是，累积释放百分比随药物浓度的增加而降低。阿司匹林会降低润湿性和溶胀速率。

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