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[基于聚乙烯醇制备亲水性基质形式的缓释制剂]

[Production of delayed-release formulations based on hydrophilic matrix forms using polyvinyl alcohol].

作者信息

Süss W

出版信息

Pharmazie. 1983 Jul;38(7):476-8.

PMID:6415679
Abstract

By increasing the drug concentration or the porosity of the mouldings, the liberation rate of the drug is increased. Dependently on their wetting behaviour and concentration, insoluble solids may exert varied effects on the liberation rate. The rate of swelling and, thus, the disintegration time and the release can be controlled by the addition of magnesium stearate or potato starch.

摘要

通过增加药物浓度或模制品的孔隙率,可提高药物的释放速率。取决于它们的润湿行为和浓度,不溶性固体可能对释放速率产生不同的影响。可通过添加硬脂酸镁或马铃薯淀粉来控制溶胀速率,进而控制崩解时间和释放。

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