Johnson Luke H, Son Heehwa G, Ha Dat Thinh, Strickley John D, Joh Joongho, Demehri Shadmehr
University of Louisville School of Medicine, Louisville, Kentucky, USA.
Center for Cancer Immunology, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
JID Innov. 2022 Sep 29;3(2):100163. doi: 10.1016/j.xjidi.2022.100163. eCollection 2023 Mar.
Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer, with increased incidence in immunosuppressed patients. β-Human papillomavirus has been proposed as a contributor to cSCC risk partly on the basis of increased β-human papillomavirus viral load and seropositivity observed among patients with cSCC. Experimental data in mice colonized with mouse papillomavirus type 1 suggest that T cell immunity against β-human papillomavirus suppresses skin cancer in immunocompetent hosts, and the loss of this immunity leads to the increased risk of cSCC. In this study, we show that CD8 T cell depletion in mouse papillomavirus type 1‒colonized mice that underwent skin carcinogenesis protocol led to increased viral load in the skin and seropositivity for anti‒mouse papillomavirus type 1 antibodies. These findings provide evidence that compromised T cell immunity can be the link that connects increased β-human papillomavirus detection to cSCC risk.
皮肤鳞状细胞癌（cSCC）是第二常见的癌症，在免疫抑制患者中的发病率有所增加。有人提出β-人乳头瘤病毒是cSCC风险增加的一个因素，部分依据是在cSCC患者中观察到β-人乳头瘤病毒病毒载量增加和血清阳性率升高。在感染1型小鼠乳头瘤病毒的小鼠中进行的实验数据表明，针对β-人乳头瘤病毒的T细胞免疫在免疫健全的宿主中可抑制皮肤癌，而这种免疫的丧失会导致cSCC风险增加。在本研究中，我们发现，接受皮肤致癌方案的感染1型小鼠乳头瘤病毒的小鼠中，CD8 T细胞耗竭导致皮肤中病毒载量增加以及抗1型小鼠乳头瘤病毒抗体血清阳性。这些发现提供了证据，表明T细胞免疫受损可能是将β-人乳头瘤病毒检测增加与cSCC风险联系起来的环节。
