Veugen Christianne C A F M, Dieleman Eveline, Hardeman Johannes A, Stokroos Robert J, Copper Marcel P
Department of Otorhinolaryngology, Head and Neck Surgery, Sint Antonius Hospital, Nieuwegein, The Netherlands.
Department of Otorhinolaryngology, Head and Neck surgery, UMC Utrecht, Utrecht, The Netherlands.
Int Arch Otorhinolaryngol. 2022 Aug 1;27(1):e43-e49. doi: 10.1055/s-0042-1743286. eCollection 2023 Jan.
Upper airway stimulation (UAS) with electric activation of the hypoglossal nerve has emerged as a promising treatment for patients with moderate-to-severe obstructive sleep apnea. To retrospectively analyze objective and subjective outcome measures after long-term follow-up in obstructive sleep apnea patients receiving upper airway stimulation. An observational retrospective single-center cohort study including a consecutive series of patients diagnosed with obstructive sleep apnea receiving upper airway stimulation. Twenty-five patients were included. The total median apnea-hypopnea index (AHI) significantly decreased from 37.4 to 8.7 events per hour at the 12-month follow-up ( < 0.001). The surgical success rate was 96%. Adverse events were reported by 28% of the patients. Upper airway stimulation is an effective and safe treatment for obstructive sleep apnea in patients with continuous positive airway pressure (CPAP) failure or intolerance. However, it is possible that the existing in and exclusion criteria for UAS therapy in the Netherlands have positively influenced our results.
通过电刺激舌下神经进行上气道刺激（UAS）已成为中重度阻塞性睡眠呼吸暂停患者一种有前景的治疗方法。对接受上气道刺激的阻塞性睡眠呼吸暂停患者进行长期随访后，回顾性分析其客观和主观结局指标。一项观察性回顾性单中心队列研究，纳入一系列连续诊断为阻塞性睡眠呼吸暂停并接受上气道刺激的患者。共纳入25例患者。在12个月随访时，总中位呼吸暂停低通气指数（AHI）从每小时37.4次显著降至8.7次（<0.001）。手术成功率为96%。28%的患者报告了不良事件。上气道刺激对于持续气道正压通气（CPAP）治疗失败或不耐受的阻塞性睡眠呼吸暂停患者是一种有效且安全的治疗方法。然而，荷兰现有的UAS治疗纳入和排除标准可能对我们的结果产生了积极影响。
