The potential implication of and genetic polymorphisms on resistance to antiepileptic drugs among a Jordanian epileptic population: a cross-sectional study.

BACKGROUND

Resistance to antiepileptic drugs (AEDs) remains one of the main challenges to neurologists. Polymorphisms of drug efflux transporters such as multidrug resistance () gene and target sites such as the nucleus accumbens-associated 1 ( gene have been suggested to influence the responsiveness to treatment.

AIM

Evaluation of the association of and polymorphisms with AEDs resistance among Jordanian epileptic patients.

SUBJECTS AND METHODS

86 Jordanian epileptics were included in the study. DNA was extracted and genotyping was conducted by polymerase chain reaction followed by sequencing. Nine single nucleotide polymorphisms (SNPs) on the gene and six SNPs on the gene were investigated.

RESULTS

and polymorphisms don't seem to influence the resistance to AEDs at the genotype or allele level. However, a strong association was found between rs2032588 (OR = 5; 95%CI = [1.3-18.8],  = 0.01) and AEDs resistance among males at the allele level. Also, data revealed an association between rs1128503 and AEDs resistance among females at the allele level.

CONCLUSION

The data suggest that and polymorphisms do not influence the AEDs resistance among Jordanian epileptics. However, there is a gender-dependent association between polymorphisms and resistance to AEDs at two SNPs (rs2032588 and rs1128503).