Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Department of Rheumatology and Immunology, Kailuan General Hospital, Tangshan, Hebei Province, China.
Br J Radiol. 2023 Feb 10;96(1143):20220867. doi: 10.1259/bjr.20220867.
To explore changes in cerebral blood flow (CBF) and white matter during wakeful rest in patients with obstructive sleep apnea (OSA).
The subjects comprised OSA patients and age- and sex-matched non-sleep apnea (NSA) subjects from December 2020 to December 2021. All subjects underwent structural and arterial spin labeling MRI examinations using a 3.0 T MRI scanner. Intergroup differences in regional and global CBF and white matter hyperintensities (WMHs) were analyzed.
In this study, 100 (74 males) of 750 (439 males) subjects were diagnosed with OSA, so the prevalence of OSA in the general population was 13.3% (100/750), with 16.9% (74/439) in males and 8.4% (26/311) in females. Excluding four patients with incomplete imaging data, 96 OSA patients and 103 age- and sex-matched NSA subjects were included. At global level, OSA patients showed significantly decreased CBF values in gray matter and whole brain compared to NSA subjects (gray matter: = 0.010; whole brain: = 0.021). No significant difference in CBF values was found in WM between the two groups ( = 0.250). At regional level, compared with NSA subjects, patients with OSA exhibited significantly decreased regional CBF values mainly in right parietal lobe and right temporal lobe. Moreover, OSA patients had significantly higher WMHs burden than NSA subjects ( = 0.017).
OSA patients exhibit decreased global and regional CBF values and increased WMHs burden.
These findings provide a basis for exploring neuropathological changes of OSA and for early and appropriate treatment.
探讨阻塞性睡眠呼吸暂停（OSA）患者在清醒休息时脑血流（CBF）和白质的变化。
本研究对象为 2020 年 12 月至 2021 年 12 月期间的 OSA 患者和年龄、性别匹配的非睡眠呼吸暂停（NSA）患者。所有受试者均在 3.0T MRI 扫描仪上进行结构和动脉自旋标记 MRI 检查。分析了区域性和全脑 CBF 和白质高信号（WMHs）的组间差异。
本研究中，750 例（439 例男性）受试者中有 100 例（74 例男性）被诊断为 OSA，因此 OSA 在普通人群中的患病率为 13.3%（100/750），男性为 16.9%（74/439），女性为 8.4%（26/311）。排除 4 例影像学资料不完整的患者后，共纳入 96 例 OSA 患者和 103 例年龄、性别匹配的 NSA 患者。在全脑水平，与 NSA 患者相比，OSA 患者的灰质和全脑 CBF 值明显降低（灰质： = 0.010；全脑： = 0.021）。两组间 WM 的 CBF 值无显著差异（ = 0.250）。在局部脑区水平，与 NSA 患者相比，OSA 患者的右侧顶叶和右侧颞叶的局部 CBF 值明显降低。此外，OSA 患者的 WMHs 负荷明显高于 NSA 患者（ = 0.017）。
OSA 患者表现出全脑和局部 CBF 值降低以及 WMHs 负荷增加。
这些发现为探索 OSA 的神经病理学变化以及早期和适当的治疗提供了依据。
