Ho Y H, Lim C T, Albart S A, Schee J P, Yong M C, Looi I
Sarawak Heart Center, Department of Cardiology, Malaysia.
Seberang Jaya Hospital, Clinical Research Centre, Ministry of Health, Malaysia.
Med J Malaysia. 2023 Jan;78(1):1-6.
Tuberculosis (TB) in Malaysia has estimated incidence and mortality rates of 81 cases per 100,000 people-year and 4.9 per 100,000 populations, respectively. This study aimed to study the characteristics of rural TB patients and their mortality outcomes.
This is a retrospective observational study involving real-world data analysis, looking into TB patients in Lubok Antu Health Clinic by obtaining data through clinic cards, from 1 January 2019 till 31 December 2020. Statistical significance was p < 0.05.
Eighty-four patients were included. Fifty-two (61.9%) were male. Median age was 58.5 (39-67). Forty-six (54.8%) had smear-positive TB. Seventy-eight (92.9%) were alive at treatment completion. Fifteen (17.9%) experienced adverse drug reactions. Estimated prevalence and mortality rate were 7.1% and 10.7 per 100,000 populations, respectively. Regression analyses revealed that drug reaction was significantly associated with compliance [OR = 8.38 (95% CI: 1.26, 55.53), p = 0.029]. Patients compliant with treatment were more likely to survive [OR = 12.5 (95% CI: 1.61, 97.34), p = 0.028].
Compliance with TB treatment should be emphasised to reduce TB-related mortality.
马来西亚的结核病（TB）估计发病率和死亡率分别为每10万人年81例和每10万人口4.9例。本研究旨在探讨农村结核病患者的特征及其死亡结局。
这是一项回顾性观察研究，涉及真实世界数据分析，通过诊所卡片获取2019年1月1日至2020年12月31日期间卢博克安图健康诊所的结核病患者数据。统计学显著性为p<0.05。
纳入84例患者。52例（61.9%）为男性。中位年龄为58.5岁（39 - 67岁）。46例（54.8%）痰涂片阳性结核病患者。78例（92.9%）在治疗结束时存活。15例（17.9%）出现药物不良反应。估计患病率和死亡率分别为7.1%和每10万人口10.7例。回归分析显示，药物反应与依从性显著相关[比值比（OR）= 8.38（95%置信区间：1.26，55.53），p = 0.029]。依从治疗的患者更有可能存活[OR = 12.5（95%置信区间：1.61，97.34），p = 0.028]。
应强调结核病治疗的依从性，以降低结核病相关死亡率。
