Laming P R, Rooney D J, Ferguson J
Department of Zoology, Queen's University of Belfast, Northern Ireland.
Physiol Behav. 1987;40(5):617-24. doi: 10.1016/0031-9384(87)90107-7.
Intramuscular injection of sodium penicillin in roach (Rutilus rutilus) caused delayed habituation of arousal responses to repeated presentation of the onset of illumination or of a 'tap' stimulus. Topical application of aluminum hydroxide to the telencephalon of roach had a similar effect but was shown, also, to induce electroencephalographic seizures, in which the EEG amplitude was elevated from 4-20 times its normal level. Both treatments caused intermittent, abnormal 'weaving' behaviour and sporadic, violent, uncoordinated motor activity. In goldfish, Carassius auratus, topical application of aluminum hydroxide also caused delayed habituation of quantitatively measured, cardiac arousal responses to a moving shadow stimulus, compared to controls. This delayed habituation was, however, largely a result of the elevated magnitude of these arousal responses. The results are discussed in relation to brain mechanisms normally operative during arousal which may be hyperactive in epilepsy.
在拟鲤（Rutilus rutilus）中肌肉注射青霉素钠会导致对重复呈现光照开始或“轻敲”刺激时的觉醒反应出现延迟性习惯化。将氢氧化铝局部应用于拟鲤的端脑也有类似效果，但同时还会诱发脑电图癫痫发作，其中脑电图振幅升高至正常水平的4 - 20倍。两种处理都会导致间歇性的异常“摆动”行为以及偶发的、剧烈的、不协调的运动活动。在金鱼（Carassius auratus）中，与对照组相比，局部应用氢氧化铝也会导致对移动阴影刺激的定量测量的心脏觉醒反应出现延迟性习惯化。然而，这种延迟性习惯化在很大程度上是这些觉醒反应幅度升高的结果。本文结合在觉醒过程中正常运作且在癫痫中可能过度活跃的脑机制对这些结果进行了讨论。
