Ma Cheng, Cui Di, Han Bangmin, Ding Mao, Zhang Jiahao, Liu Shiyun, Gao Yingli, Xia Shujie
Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Cancer Invest. 2023 Apr;41(4):345-353. doi: 10.1080/07357907.2023.2171050. Epub 2023 Feb 2.
The association between DM and prostate cancer progression remains controversial. Previous studies mainly focused on early stage prostate cancer patients. We aimed to study the association between DM and prostate cancer progression in locally advanced prostate cancer patients. 598 locally advanced prostate cancer patients in a top tertiary hospital in China between 2012 and 2021 were divided into three groups based on the postoperative average HbA1c level. The follow-up time is 46.96 ± 27.07 months. Three hundred and forty-eight (58.2%) were normal glucose, 175 (29.3%) were moderate glucose, and 75 (12.5%) were high glucose. Higher postoperative-average HbA1c was associated with poorer OS, PCSM, and PSA-RFS. We concluded that poorly controlled DM was correlated with poorer OS, PCSM, and PSA-RFS in locally advanced prostate cancer patients.
糖尿病（DM）与前列腺癌进展之间的关联仍存在争议。先前的研究主要集中在早期前列腺癌患者。我们旨在研究局部晚期前列腺癌患者中DM与前列腺癌进展之间的关联。2012年至2021年间，中国一家顶级三级医院的598例局部晚期前列腺癌患者根据术后平均糖化血红蛋白（HbA1c）水平分为三组。随访时间为46.96±27.07个月。348例（58.2%）血糖正常，175例（29.3%）血糖中度升高，75例（12.5%）血糖高度升高。术后平均HbA1c水平较高与总生存期（OS）、前列腺癌特异性死亡率（PCSM）和前列腺特异性抗原无进展生存期（PSA-RFS）较差相关。我们得出结论，在局部晚期前列腺癌患者中，血糖控制不佳与较差的OS、PCSM和PSA-RFS相关。
