McCann D J, Rabin R A, Winter J C
Department of Pharmacology and Therapeutics, School of Medicine, State University of New York, Buffalo 14214.
Physiol Behav. 1987;40(6):805-12. doi: 10.1016/0031-9384(87)90288-5.
Effects of drugs known to disrupt performance in an 8-arm radial maze are reported in terms of changes caused in the pattern of arm entry. Phencyclidine (PCP) and N-allyl-N-normetazocine (SKF-10,047) alter the pattern of arm entry in a way which distinguishes their actions from those of scopolamine and certain serotonergic agonists. The apparent rank order of potencies for causing this effect is (+)SKF-10,047 greater than PCP greater than (-)SKF-10,047. Results of previous radial maze studies evaluating the interactions of clonidine and verapamil with PCP are summarized. Data are reported which indicate that the ability of verapamil to potentiate PCP's behavioral effects stems from an alteration of the pharmacokinetics of PCP; when verapamil (20 mg/kg, IP) was administered 15 minutes before [3H]PCP (40 microCi/kg, IP), brain levels of tritium were increased by 154 to 225 percent. Finally, possible advantages of using a 4-arm radial maze in studies of PCP and related drugs are discussed.
已知会干扰八臂放射状迷宫表现的药物效应，是根据臂进入模式的变化来报告的。苯环己哌啶（PCP）和N-烯丙基-N-去甲左啡诺（SKF-10,047）改变臂进入模式的方式，使其作用区别于东莨菪碱和某些血清素能激动剂。引起这种效应的效力明显顺序是（+）SKF-10,047大于PCP大于（-）SKF-10,047。总结了先前评估可乐定和维拉帕米与PCP相互作用的放射状迷宫研究结果。报告的数据表明，维拉帕米增强PCP行为效应的能力源于PCP药代动力学的改变；当在注射[3H]PCP（40微居里/千克，腹腔注射）前15分钟注射维拉帕米（20毫克/千克，腹腔注射）时，脑中氚水平增加了154%至225%。最后，讨论了在PCP及相关药物研究中使用四臂放射状迷宫的可能优势。
