Centro de Ojos Quilmes, Humberto Primo, 298, Quilmes, Buenos Aires, Argentina.
Int Ophthalmol. 2023 Jul;43(7):2407-2417. doi: 10.1007/s10792-023-02640-2. Epub 2023 Jan 30.
To evaluate the efficacy of micropulse transscleral cyclophotocoagulation (MP-TSCPC) considering different characteristics: glaucoma subtypes and lens status.
A retrospective case-series study was designed to evaluate intraocular pressure (IOP), and the number of IOP-lowering medications, used by glaucoma patients treated with MP-TSCPC between 2016 and 2019. Cases had a follow-up period of 12 months. Achieving an IOP reduction higher than 20%, or the decrease of at least one IOP-lowering medication, was considered a successful outcome. The same population was analyzed by classifying them in two groups as: glaucoma subtypes and lens status. The baseline spherical equivalent (SE) was also calculated for considering association with the achieved IOP.
A total of 86 eyes were included. In most cases, IOP and IOP-lowering medications were decreased with a statistically significant difference (p < 0.0001), and all of them had a successful outcome. The percentage of IOP drop oscillated between 25.9% (open-angle glaucoma sub-group) and 37.5% (pseudoexfoliative glaucoma sub-group), 12 months after surgery. The difference between the groups was not statistically significant (p 0.20 and 0.32 for glaucoma subtypes and lens status, respectively). The Pearson's coefficient obtained was low for the SE and IOP association, at the 12 -month postoperative mark (- 0.009; p < 0.001).
The MP-TSCPC treatment was successful in decreasing IOP and IOP-lowering medications, in different glaucoma subtypes. Differences between groups (glaucoma subtypes, phakic and pseudophakic eyes) were not statistically significant. No association was found between the SE and the IOP achieved value after MS-TSCPC treatment.
评估微脉冲经巩膜睫状体光凝术(MP-TSCPC)的疗效,考虑不同特征:青光眼亚型和晶状体状态。
设计了一项回顾性病例系列研究,以评估 2016 年至 2019 年间接受 MP-TSCPC 治疗的青光眼患者的眼内压(IOP)和降眼压药物数量。病例的随访时间为 12 个月。将 IOP 降低 20%以上或至少减少一种降眼压药物定义为治疗成功。将同一人群分为两组进行分析:青光眼亚型和晶状体状态。还计算了基线等效球镜(SE),以考虑与达到的 IOP 的关联。
共纳入 86 只眼。大多数情况下,IOP 和降眼压药物均显著降低(p<0.0001),且均达到治疗成功。IOP 下降百分比在手术后 12 个月时波动在 25.9%(开角型青光眼亚组)和 37.5%(剥脱性青光眼亚组)之间,组间差异无统计学意义(p=0.20 和 0.32 分别用于青光眼亚型和晶状体状态)。在术后 12 个月时,SE 和 IOP 之间的 Pearson 系数相关性较低(-0.009;p<0.001)。
MP-TSCPC 治疗可成功降低不同青光眼亚型的 IOP 和降眼压药物。组间差异(青光眼亚型、有晶状体眼和无晶状体眼)无统计学意义。在 MS-TSCPC 治疗后,SE 与达到的 IOP 值之间未发现相关性。