Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Odisha 769008, India.
Biomed Mater. 2023 Feb 9;18(2). doi: 10.1088/1748-605X/acb74e.
Currently, one of the most severe clinical concerns is post-surgical tissue adhesions. Using films or hydrogel to separate the injured tissue from surrounding tissues has proven the most effective method for minimizing adhesions. Therefore, by combining dual crosslinking with calcium ions (Ca) and tetrakis(hydroxymethyl) phosphonium chloride, we were able to create a novel, stable, robust, and injectable dual crosslinking hydrogel using albumin (BSA). This dual crosslinking has preserved the microstructure of the hydrogel network during the degradation process, which contributes to the hydrogel's mechanical strength and stability in a physiological situation. At 60% strain, compressive stress was 48.81 kPa obtained. It also demonstrated excellent self-healing characteristics (within 25 min), tissue adhesion, excellent cytocompatibility, and a quick gelling time of 27 ± 6 s. Based on these features, the dual crosslinked injectable hydrogels might find exciting applications in biomedicine, particularly for preventing post-surgical adhesions.
目前，临床上最严重的问题之一是术后组织粘连。使用薄膜或水凝胶将受伤组织与周围组织隔开，已被证明是减少粘连的最有效方法。因此，我们通过将双重交联与钙离子（Ca）和四羟甲基氯化鏻结合，使用白蛋白（BSA）成功地制备了一种新型的、稳定的、坚固的、可注射的双重交联水凝胶。这种双重交联在降解过程中保留了水凝胶网络的微观结构，有助于水凝胶在生理环境下保持机械强度和稳定性。在 60%的应变下，压缩应力为 48.81 kPa。它还表现出优异的自修复特性（在 25 分钟内）、组织粘附性、优异的细胞相容性和快速凝胶化时间（27 ± 6 s）。基于这些特性，双重交联可注射水凝胶可能在生物医学领域有令人兴奋的应用，特别是用于防止术后粘连。
