Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, Guangdong 510630, China.
Department of Bioinformatics, Hugobiotech, Beijing, China.
J Mycol Med. 2023 May;33(2):101357. doi: 10.1016/j.mycmed.2023.101357. Epub 2023 Jan 12.
Cryptococcus gattii (C. gattii) has been considered a leading cause of meningitis in immunocompetent hosts in tropical and subtropical regions. Visual loss is common but hearing impairment is relatively infrequent in C. gattii meningitis. Notably, there have been limited studies on the etiology, and especially therapy of auditory and ocular complications associated with C. gattii meningitis. Here we report a case of reversible deafness and blindness treated with a ventriculoperitoneal shunt (VPS) surgery in C. gattii meningitis. This case indicated that elevated intracranial pressure (ICP) may play a role in the concurrent hearing and vision impairments associated with C. gattii meningitis and the early VPS surgery after the initiation of the antifungal therapy may effectively improve both hearing and vision in this condition.
新型隐球菌（C. gattii）被认为是热带和亚热带地区免疫功能正常宿主中脑膜炎的主要病因。新型隐球菌性脑膜炎患者常出现视力丧失，但听力损伤相对较少。值得注意的是，目前关于新型隐球菌性脑膜炎相关听觉和眼部并发症的病因，尤其是治疗方法的研究有限。本研究报告了 1 例新型隐球菌性脑膜炎患者，采用脑室-腹腔分流术（VPS）治疗，其耳聋和失明可逆。该病例表明，颅内压升高（ICP）可能与新型隐球菌性脑膜炎相关的听力和视力障碍有关，在抗真菌治疗开始后早期行 VPS 手术可能有效改善这种情况下的听力和视力。
