Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Montesano 49, 80131 Naples, Italy.
Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, D-07743 Jena, Germany.
Fitoterapia. 2023 Apr;166:105439. doi: 10.1016/j.fitote.2023.105439. Epub 2023 Jan 28.
Rhodiola rosea roots and rhizomes hold an important place in the folk medicines of Russia, Scandinavia, Mongolia, and China as a health supplement for stimulating the nervous system, enhancing physical and mental performances, and nowadays they constitute the active ingredient in many popular commercial preparations sold worldwide as food additives, pharmaceutical remedies, and drinks. This study was aimed at providing a detailed phytochemical characterization of the Rhodiola 5%, a commercially available extract of R. rosea roots, and resulted in the characterization of 18 secondary metabolites, including 13 polyphenols and 6 terpenoids, and in the discovery of the new rhodiosidin (5), the first R. rosea metabolite to show both terpenoid and cinnamoyl moieties. The 5-lipoxygenase inhibiting activity of the main components was characterized and disclosed that rosiridin (6), kenposide A and rosavins are mainly responsible for this activity of the extract.
红景天根和根茎在俄罗斯、斯堪的纳维亚、蒙古和中国的民间医学中占有重要地位，是一种刺激神经系统、增强身心表现的保健品，如今，它们构成了许多在全球范围内作为食品添加剂、药物制剂和饮料销售的流行商业制剂的活性成分。本研究旨在对市售红景天 5%提取物进行详细的植物化学表征，结果鉴定了 18 种次生代谢产物，包括 13 种多酚和 6 种萜类化合物，并发现了新的红景天苷（5），这是第一个同时具有萜类和肉桂酰部分的红景天代谢物。对主要成分的 5-脂氧合酶抑制活性进行了表征，并揭示了罗西丁（6）、京宝素 A 和罗萨文是提取物中这种活性的主要成分。
