基于环糊精/聚乙烯吡咯烷酮的含提取物纳米纤维作为提高活性成分生物利用度的新体系

Cyclodextrin/PVP-Based Nanofibers with Extract as a New System for Increasing Bioavailability of Active Components.

作者信息

Jaskólski Maciej, Paczkowska-Walendowska Magdalena, Rybarczyk Zuzanna, Rosiak Natalia, Miklaszewski Andrzej, Cielecka-Piontek Judyta

机构信息

Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.

Faculty of Mechanical Engineering and Management, Institute of Materials Science and Engineering, Poznan University of Technology, 60-965 Poznan, Poland.

出版信息

Molecules. 2025 Aug 13;30(16):3359. doi: 10.3390/molecules30163359.

DOI:10.3390/molecules30163359

PMID:40871512

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12388008/

Abstract

The present study aimed to optimize the extraction process for root, then develop and optimize electrospun nanofiber systems containing extract to enhance the bioavailability of its active compounds, salidroside and rosarin. Using a Design of Experiments (DoE) approach, nanofibers were prepared with varying ratios of polyvinylpyrrolidone (PVP) and hydroxypropyl-cyclodextrins (HPαCD, HPβCD, HPγCD). The systems were comprehensively characterized in terms of morphology, content of active compounds, dissolution rate, permeability, mucoadhesion, antioxidant, and anti-inflammatory activities. The results showed that nanofiber formulations significantly improved the dissolution and permeability of salidroside and rosarin compared to the crude extract. The antioxidant properties were notably enhanced, while the anti-inflammatory activity varied depending on composition. The formulation containing 3 g HPβCD and 2.5 g PVP demonstrated the most favorable balance of functional and technological properties. Principal Component Analysis (PCA) and correlation matrix analysis confirmed that system composition strongly influenced the interrelationships between technological parameters and bioactivity. These findings indicate that electrospun nanofibers based on cyclodextrin-PVP matrices are a promising preclinical strategy for improving the delivery of bioactives.

摘要

本研究旨在优化[药材名称]根的提取工艺，然后开发并优化含有提取物的电纺纳米纤维系统，以提高其活性成分红景天苷和玫瑰红景天苷的生物利用度。采用实验设计（DoE）方法，制备了含有不同比例聚乙烯吡咯烷酮（PVP）和羟丙基环糊精（HPαCD、HPβCD、HPγCD）的纳米纤维。对这些系统在形态、活性成分含量、溶解速率、渗透性、粘膜粘附性、抗氧化和抗炎活性等方面进行了全面表征。结果表明，与粗提取物相比，纳米纤维制剂显著提高了红景天苷和玫瑰红景天苷的溶解和渗透性能。抗氧化性能显著增强，而抗炎活性则因组成而异。含有3 g HPβCD和2.5 g PVP的制剂在功能和技术性能方面表现出最有利的平衡。主成分分析（PCA）和相关矩阵分析证实，系统组成强烈影响技术参数与生物活性之间的相互关系。这些发现表明，基于环糊精 - PVP基质的电纺纳米纤维是一种有前途的改善生物活性物质递送的临床前策略。