肌动蛋白可能针对脊髓损伤患者加速的认知衰老：一项系统的专题综述。
Myokines may target accelerated cognitive aging in people with spinal cord injury: A systematic and topical review.
作者信息
Vints Wouter A J, Levin Oron, Masiulis Nerijus, Verbunt Jeanine, van Laake-Geelen Charlotte C M
机构信息
Department of Health Promotion and Rehabilitation, Lithuanian Sports University, Sporto str. 6, LT-44221 Kaunas, Lithuania; Department of Rehabilitation Medicine Research School CAPHRI, Maastricht University, P.O. Box 616, 6200 MD Maastricht, the Netherlands; Centre of Expertise in Rehabilitation and Audiology, Adelante Zorggroep, P.O. Box 88, 6430 AB Hoensbroek, the Netherlands.
Department of Health Promotion and Rehabilitation, Lithuanian Sports University, Sporto str. 6, LT-44221 Kaunas, Lithuania; Movement Control & Neuroplasticity Research Group, Group Biomedical Sciences, Catholic University Leuven, Tervuursevest 101, 3001 Heverlee, Belgium.
出版信息
Neurosci Biobehav Rev. 2023 Mar;146:105065. doi: 10.1016/j.neubiorev.2023.105065. Epub 2023 Jan 28.
Persons with spinal cord injury (SCI) can suffer accelerated cognitive aging, even when correcting for mood and concomitant traumatic brain injury. Studies in healthy older adults have shown that myokines (i.e. factors released from muscle tissue during exercise) may improve brain health and cognitive function. Myokines may target chronic neuroinflammation, which is considered part of the mechanism of cognitive decline both in healthy older adults and SCI. An empty systematic review, registered in PROSPERO (CRD42022335873), was conducted as proof of the lack of current research on this topic in people with SCI. Pubmed, Embase, Cochrane and Web of Science were searched, resulting in 387 articles. None were considered eligible for full text screening. Hence, the effect of myokines on cognitive function following SCI warrants further investigation. An in-depth narrative review on the mechanism of SCI-related cognitive aging and the myokine-cognition link was added to substantiate our hypothetical framework. Readers are fully updated on the potential role of exercise as a treatment strategy against cognitive aging in persons with SCI.
脊髓损伤（SCI）患者即使在校正情绪和并发的创伤性脑损伤后，仍可能出现认知加速老化。对健康老年人的研究表明，肌动蛋白（即运动期间肌肉组织释放的因子）可能改善大脑健康和认知功能。肌动蛋白可能针对慢性神经炎症，而慢性神经炎症被认为是健康老年人和脊髓损伤患者认知衰退机制的一部分。为了证明目前在脊髓损伤患者中缺乏关于该主题的研究，我们进行了一项在PROSPERO（CRD42022335873）注册的空白系统评价。检索了PubMed、Embase、Cochrane和科学网，共获得387篇文章。没有一篇被认为符合全文筛选的条件。因此，肌动蛋白对脊髓损伤后认知功能的影响值得进一步研究。我们还增加了一篇关于脊髓损伤相关认知老化机制和肌动蛋白-认知联系的深入叙述性综述，以证实我们的假设框架。读者可以全面了解运动作为脊髓损伤患者对抗认知老化的治疗策略的潜在作用。
Zotero 插件