Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas, United States.
Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States.
Am J Physiol Cell Physiol. 2023 Mar 1;324(3):C707-C717. doi: 10.1152/ajpcell.00132.2022. Epub 2023 Jan 30.
A better understanding of the mechanisms regulating cancer metastasis is critical to develop new therapies and decrease mortality. Emerging evidence suggests that the interactions between tumor cells and the host immune system play important roles in establishing metastasis. Tumor cells are able to recruit immune cells, which in turn promotes tumor cell invasion, intravasation, survival in circulation, extravasation, and colonization in different organs. The tumor-host immunological interactions also generate a premetastatic niche in distant organs which facilitates metastasis. In this review, we summarize the recent findings on how tumor cells and immune cells regulate each other to coevolve and promote the formation of metastases at the major organ sites of metastasis.
更好地理解调控癌症转移的机制对于开发新的治疗方法和降低死亡率至关重要。新出现的证据表明，肿瘤细胞与宿主免疫系统之间的相互作用在建立转移中起着重要作用。肿瘤细胞能够招募免疫细胞，而免疫细胞反过来又促进肿瘤细胞的侵袭、血管内渗、在循环中的存活、血管外渗以及在不同器官的定植。肿瘤-宿主免疫相互作用还在远处器官中产生有利于转移的前转移龛。在这篇综述中，我们总结了最近的研究结果，即肿瘤细胞和免疫细胞如何相互调节以共同进化并促进转移在主要转移器官部位的形成。
